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Academy of Pharmaceutical Sciences
first session Monday, April 25, 9:00 a.m.-Adolphus, Roof Garden 1. 2.
3.
4. 5.
Call to order Officers' reports Pharmaceutical Services to Nursing Homes A. Provisions for Pharmaceutical Services in Small Minnesota Hospitals-Hugh F. Kabat B. Address-Alfred Ercolano, executive secretary, American Nursing Home Association C. Address-Donald P. Conwell, MD, USPHS D. Address-Henry H. Henley, president, McKesson and Robbins E. Pharmaceutical Service to Nursing Homes-premier showing of filmstrip Five workshop sessions S{Jmmary and workshop reports
A cad em y pre s idents-Takeru Higuchi (left), pharmaceutical sciences, and Raymond L. Dunn, general practice of pharmacy.
Academy secretaries-Sa m u el W. Gold s t e i n (left), pharmaceutical sciences, and John T. Fay, Jr., general practice of pharmacy.
second session Tuesday, April 26, 9:00 a.m.-DMA Theatre (Meeting jointly with American College of Apothecaries) Public and Professional Communications
1. 2. 3. 4.
Demonstration of Physician Detailing by Pharmacists The Television Image of the Pharmacist Are the American People Being Told Too Much about Drugs? The Use of RPh as part of the Pharmacist's Signature
th i rd session Wednesday, April 27, 9:00 a.m.-Adolphus, Grand Ballroom Aids to Professional Practice
1.
2. 3.
4. 5. 6. 7.
Population and the Prescribing Habits of Physicians-Charles L. Braucher Prescription Pricing and the Professional Fee-Harry A. Smith Problem Prescriptions: Some Analyses for the Practicing Pharmacist-V. Jean Brown New Pharmaceutical Centers-James E. Allen and Emil Martini, Jr. Problems that Occur Commonly in Community Practicepremier showing of film Five workshop sessions Summary and workshop reports
fou rth session Thursday, April 28, 9:00 a.m.-Baker, Crystal Ballroom 1. 2. 3. 4. 5.
Community Pharmacies' Economic Growth Curves-R.W. Hammel A Study of the Purchasing Practices of the Community Pharmacies of the State of Mississippi-B.J. Keller Complete Directions for Prescriptions-Allen J. Brands Prepared Prescription Insurance in Rural Communities-D.N. Hansell Panel: Understanding Public Law 89-97 Moderator-Wallace Werble, editor, F-D-C Reports Panelists Solomon J. Axelrod, MD, University of Michigan school of public health John W. Cashman, director, division of medical care administration, U.S. Public Health Service, Department of Health , Education and Welfare Fred H. Steininger, director, bureau of family services, Welfare Administration, Department of Health, Education and Welfare
fifth session
4.
Over-the-Counter Compounds with Sedative Properties-C.K. Erickson 5. Expectorants and Cough Depressants-R.K. Chalmers 6. Burn and Sunburn Remedies-N.A. Hall 7. Antihistamines and other Allergic Aids-M.H. Weinswig
academy of pharmaceutical sciences President-Takeru Higuchi President· elect-Joseph V. Swintosky Vice President-George P. Hager Pa st President-Jack Cooper Secretary-Samuel W. Goldstein Membership -a t -La rge Representatives-John E. Christian, Howard J. Schaeffer and George H. Schneller
executive committee Sunday, April 24, 3:00 p.m.-DMA 201
business meeting Wednesday, April 27, 9:40 a.m.-Baker, Crystal Ballroom 1. Call to order 2. Reading of communications 3. President's address-Takeru Higuchi 4. Secretary's report-Samuel W. Goldstein 5. Committee reports A. International honors-Takeru Higuchi B. Finance-Jack Cooper C. Membership-George P. Hager D. Sections-Joseph V. Swintosky E. Spheres of interest and organization-Joseph V. Swintosky F. Nominations and elections-Harry B. Kostenbauder G. Bylaws and procedural guides-George H. Schneller H. Patents policy-W. Lewis Nobles I. Smoking and Health-George H. Schneller J . Animal experimentation-Joseph P. Buckley K. Metric system-Joseph V. Swintosky L. Coordination with APhA, ASHP and Academy of General Practice of Pharmacy-Ben F. Cooper M. Symposia and meetings-Louis W. Busse N. Communications-Ralph S. Levi O. Resolutions-John E. Christian 6. New business 7. Adjournment
Thursday, April 28, 2:00 p.m.-Baker, Crystal Ballroom
luncheon
Home Medication in Review
Wednesday, April 27, 12:00 noon-Baker, Lounge
1.
The Public, the Pharmacist and Self Medication-D.A. Knapp 2. Antacids-R.P. Penna 3. The Pharmacist, Acne and Nonprescription Acne MedicationsR.L. Day
120
Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION
executive committee breakfast Friday, April 29, 7:30 a.m.-Adolphus, Parlor C
academy sections scientific Chairman-Robert F. Doerge Chairman -elect-Dale E. Wurster Vice Chairman-Harry B. Kostenbauder ~;ecretary-Rudolph H. Blythe (Papers submitted to the scientific section for presentation at the Dallas meeting were accepted by the secretary of that section but are tIeing presented here by the appropriate "new sections." This has been done in order to expedite the development of the Academy and the several sections representing specific areas of interest.)
breakfast Monday, April 25, 7:30 a.m.-Adolphus, Civic Room II (Executive committee of Academy and presiding officers for sessions on contributed papers.)
first session Tuesday, April 26, 9:00 a.m.-Baker, Crystal Ballroom Industrial Pharmacy and Scientific Sections' Joint SymposiumPresent Concepts of the Biopharmaceutics of Oral Dosage Forms (see industrial pharmacy section for program)
9:45 a.m.-4. Kinetics of Reactions Involved in Penicillin Allergy I. Mechanism of Reaction of Penicillins with Glycine in Alkaline Solution-M.A. Schwartz and Gay-May Wu 10:00 a.m.-5. Utilization of a Model Copolymer to Evaluate the Contribution of Hydrophobic Bonding in Drug Binding-J.B. Nagwekar and H.B. Kostenbauder 10:15 a.m.-6. Interaction of Nonionic Hydrophilic Polymers with Phenols II. Interaction of Phenol, Tannin and Hydroxyphenols with Certain Polyethylene Glycols-B.N. Kabadi and E.R. Hammarlund 10:30 a.m.-7. Diffuse Reflectance Studies of Solid-Solid Interactions II. Interaction of Metallic and Nonmetallic Adjuvants with Anthracene, Prednisone and Hydrochlorothiazide-Michael Bornstein,Ting-fong Chin and John L. Lach 10:45 a.m.-8. Diffuse Reflectance Studies of Solid-Solid Interactions Ill. I nteraction Studies of Oxytetracycline with Metallic and Nonmetallic Adjuvants-John L. Lach and Michael Bornstein 11:00 a.m.-g. Interaction of a Group of Weak Organic Acids and Phenols with Nylon-6-Michael B. Rodell, Wallace L. Guess and John Autian 11:15 a.m.-IO. Permeation Studies of Selected Preservatives through Polyethylene-Mario A. Gonzalez, Wallace L. Guess and John Autian 11:30 a.m.-l1. Sorption and Diffusion Studies of Dicarboxylic Acids with Nylon, 6,6- Part II-R. Kent Stobaugh, H. Berg, W.L. Guess and J. Autian 11:45 a.m.-12. Molecular Orbital Calculations on Sulfonamide Molecules-E.C. Foernzler and A.N. Martin
second session
second session
Monday, April 25, 1:30 p.m.-DMA Room 3A
Tuesday, April 26, 9:00 a.m.-Baker, Terrace Room
Presiding-Louis J. Ravin and John A. Biles
Medicinal Chemistry and Scientific Sections' Joint SymposiumAdvances in Natural Product Chemistry (see section on medicinal chemistry for program)
third session-business Wednesday, April 27, 9:00 a.m.-Baker, Crystal Ballroom 1.
Call to order Chairman's address-Robert F. Doerge Secretary's report-Rudolph H. Blythe Treasurer' s report-Rudolph H. Blythe Committee reports A. Auditing-Louis J. Ravin B. Ebert prize-Howard J. Schaeffer C. Kilmer prize-Melvin R. Gibson D. Physiological testing-Frederick C. Armstrong E. Awards and prizes-E. Roy Hammarlund 6. Unfinished business 7. New business A. Consideration of section dissolution 8. Adjournment
2. 3. 4. 5.
1:30 p.m.-B. The Influence of Ions and Urea on the Surface Activity of Chlorpromazine-Rashmikant M. Patel and George Zografi 1:45 p.m.-14. The Effect of Micelle Formation on the Concen tration Dependence of Surface Tension-Albert J. Flood and L. Dallas Tuck 2:00 p.m.-15. The Effects of Aging and Surfactant Concentration on the Rheology and Droplet Size Distribution of a Nonaqueous Emulsion-R.D. Hamill and R.V. Petersen 2:15 p.m.-16. The Effect of Surfactant Concentration on the Interfacial Viscosity of a Nonaqueous System-R.D. Hamill and R.V. Petersen 2:30 p.m.-17. Kinetics of Metabolism and Urinary Excretion of Dextrorotatory and Levorotatory Mandelic Acid in Humans-J.B. Nagwekar and H.B. Kostenbauder 2:45 p.m.-18. Acetylsalicylic Acid Hydrolysis in Human Blood and Plasma. I. Methodology and in Vitro Studies-P.A. Harris and S. Riegelman
fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Cactus Room Drug Standards, Analysis and Control and Scientific Sections' Joint Symposium-The Appl ication of Analytical Technics to the Stability of Drugs (see section on drug standards, analysis and control for program)
basic pharmaceutics Chairman-Dale E. Wurster Chairman-elect-John A. Biles Vice Chairman-Harry B. Kostenbaudet Secretary-James E. Tingstad
Academy section chairmen-(Ieft to right, above) Robert F. Doerge, scientific; Dale E. Wurster, basic pharmaceutics, and Lloyd C. Miller, drug standards, analysis and control.
Academy section secretaries-(Ieft to right, below) Rudolph H. Blythe, scientific; James E. Tingstad, basic pharmaceutics, and Dale H. Szulcewski, drug standards, analysis and control.
fi rst session Monday, April 25, 9:00 a.m.-DMA Room 3A Presiding-John L. Lach and John Autian 9:00 a.m.-I. Transition Metal Complexes of Substituted Thiouracils-Edward R. Garrett and Dennis J. Weber 9:15 a.m.-2. The Thermodynamics of Chelation by TetracyclinesLeslie Z. Benet and Jere E. Goyan 9:30 a.m.-3 . A Comparison of the Solubility, Spectral and Kinetic Technics for Studying Complex Formation-Joseph A. Mollica, Jr. and Kenneth A. Connors
Vol. NS6, No. 3, March 1966
121
3:00 p.m.-ISa. Theoretical Formulation of Sustained Release Dosage Forms-J.R. Robinson, H. Stelmach and S.P. Eriksen 3:15 p.m.-Business meeting
third session Tuesday, April 26, 2:30 p.m.-Baker, Texas Room Presiding-Edward G. Rippie and David E. Guttman 2:30 p.m.-19. Interaction of Di- and Tri-Carboxylic Acids with Glutaric Anhydride in Aqueous Solution-J.R. Robinson, A.J. Repta and T. Higuchi 2:45 p.m.-20. Interaction of Acetic Anhydride with Citrate Ions in Aqueous Solution-A. J. Repta, J. R. Robinson and T. Higuchi . 3:00 p.m.-2L Catalytic Effect of Copper (II) Ion on th e HydrolYSIS of Some Esters and Amides-A.J. Agren 3:15 p.m.-22. Kinetics of Solvolysis of Various N,N ' -Disubstituted N-Nitrosoureas in Neutral and Alkaline Solution-Edward R. Garrett and Shigeru Goto 3:30 p.m.-23. Kinetics of Solvolysis of Some 3- and 3,4-Substituted Sydnones-Edward R. Garrett and Parimal J. Mehta 3:45 p.m.-24. Kinetics and Mechanisms of Hydrolysis or I-Substituted 6-Amino-2-Thiouracils-Ting-fong Chin, Wen-hung Wu and John L Lach 4:00 p.m.-25. The Hydrolytic Behavior of Riboflavin and Related Isoalloxazines 1. Studies with 9-Methylisoalloxazine-D.A. Wadke and D.E. Guttman 4:15 p.m.-26. The Hydrolytic Decomposition of Sodium Sulfacetamide in Selected Aqueous Systems-Sr. Francis Mary Schleider, OP, D.M. Eno, J.A. Feldman and A.M. Galinsky 4:30 p.m.-27. The Photochemical Formation of Hydrogen Peroxide in White Lotion USP-E.P Guth and Z. Mansour 4:45 p.m.-2S. The Effect of Organic Inhibitors on in Vitro Activity of Several Antacids-H. Stromberg and R.C. Brogle
fou rth session
9:45 a.m.-44. Factors Affecting the Absorption of Riboflavin in Man-Gerhard Levy and W.J. Jusko 10:00 a.m.-45. The Metabolism of C14 Labeled Glutamic and Pyroglutamic Acid in Animals-W.E. Lange and E.F. Carey 10:15 a.m.-46. Effect of pH on the in Vitro Absorption of Flufenamic Acid-Armando J. Aguiar and Richard J. Fifelski 10:30 a.m.-47 _ The Effect of Some Nonionic Surfactants on the Rate of Release of Aminophylline from Suppositories-J.M. Plaxco, Jr. and C.B. Free 10:45 a.m.-4S. In Vivo Pharmacodynamic Evaluation of Oral Dosage Forms by Whole Body Liquid SCintillometry-G. Hecht, J.E. Christian and G.S. Banker 11:00 a.m.-49_ Studies on the Mechanism of Action of Phenolic Disinfectants VII. Factors Affecting Binding of Phenol Derivatives to Micrococcus Lysodeikticus Cells-J. Judis 11:15a.m.- 50. A Mathematical Treatment of Repetitive-Dose Kinetics-King Chiu Kwan, Maurice P. Zirrith, Robert A. Castello and Arnold D. Marcus 11:30 a.m.-5L Effect of Inert Tablet Ingredients on Drug Absorption Part II. Effect of Various Adjuvants on the Dissolution Rate and Intestinal Absorption of Salicylic Acid-Ganga S. Pandey, Leslie Z. Benet, William E. Johnson and V.N. Bhatia 11:45 a.m.-52. A Study of Possible Mutagenic Effects of Gamma Radiation on Antibiotic-Producing Actinomycetes-Ada R. Dogger and James P. Vacik
drug standards, analysis and control Ch airman-Lloyd C. Miller Chairman-elect-Klaus Florey Vice Chairman-William J. Mader Secretary-Dale H. Szulcewski
first session-business Monday, April 25, 9:00a.m.-DMA Room 3B
Thursday, April 28, 9:00 a.m.-Adolphus, Cactus Room Presiding-William I. Higuchi and James E. Tingstad 9:00a.m.-29. Investigation of Factors Controlling Release of Solid Drug Dispersed in Inert Matrices II. Quantitation of ProceduresS.J. Desai, A.P. Simonelli and W.l. Higuchi 9:15 a.m.-30. Release of Drug Dispersed in Inert Matrices 111. Some Cases Involving the Polyethylene Matrix-S.J. Desai, P. Singh, W.I. Higuchi and A.P. Simonelli 9:30 a.m.-3L The Solubility of the Xanthines, Antipyrine and Several Derivatives in Syrup Vehicles-A.N. Paruta and B.B. Sheth 9:45 a.m.-32 . The Solubility of Succinic Acid in Binary Mixtures as a Function of the Dielectric Constant-A.N. Paruta 10:00 a.m .-33 . Solubilization of Gluco-Corticoids by Aqueous Solutions of Triton WR-1339-Witold Saski 10:15 a.m.-34 . Studies of the Crystal Growth Kinetics and Mechanisms of Sulfathiazole and Methylprednisolone in Various Solvents-P.O. Bernardo and W.I. Higuchi 10:30 a.m.-35. Dissolution Rate Behavior of the Polymorphic Forms of Sulfathiazole and Methylprednisolone-P.O. Bernardo, S.C. Mehta and W.I. Higuchi 10:45 a.m.-36 . Heats of Transition of Methylprednisolone and Sulfathiazole by a Differential Thermal Analysis Method-J. Keith Guillory 11:00 a.m.-37. The Influence of the State of Molecular Aggregation on the Enzymic Hydrolysis of Arylsulfate Esters-T.H. Baxter and H.B. Kostenbauder 11:15 a.m.-3S. Studies on the Aggregation of Denatured Proteins 1. Methodology Based on the Multichannel Particle Counter and Analyzer-N.F.H. Ho and W.I. Higuchi 11:30 a.m.-39. Aggregation of Certain Medicinal Amines in Aqueous Solution of Their Salts-B. Farhadieh, E.R. Hammerlund and N.A. Hall 11:45 a.m.-40. Negative Thixotropy in Flocculated Clay Suspensions-J.C. Samyn and W.Y. Jung
fifth session Friday, April 29, 9:00 a.m.-Adolphus, Danish Room Presiding-Theodore D. Sokoloski and James A. Seitz 9:00 a.m.-4L Hemolysis of Erythrocytes by Antibacterial Preservatives III. Influence of Dimethylsulfoxide on the Hemolytic Activity of Phenol-H.C. Ansel and W.F. Leake 9:15 a.m.-42. A Study of the Retention, Excretion and Distribution of 2,3,5-Triiodobenzoic Acid and Its Metabolites in the Rat-R.D. Ice, C.E. Breckinridge, Jr. and J.E. Christian 9:30 a.m.-43. Physicochemical and Physiologic Factors Affecting the Absorption of Warfarin in Man-R.A. O'Reilly, Eino Nelson and Gerhard Levy
122
Journal of the. AMERICAN PHARMACEUTICAL ASSOCIATION
second session Monday, April 25, 1:30 p.m.-DMA Room 3B Presiding-Lester Chafetz and Richard Poe 1:30 p.m.-I. Determination of Aspirin and Barbiturate Combinations by Nonaqueous Titration-Song-Ling Lin and M.l. Blake 1:45 p.m.-2. The Effect of Diester Type Plasticizers on the Differential Thermal Spectrum of a Polyvinyl Chloride System- R.K. O'Leary, J. Foy, W.L Guess and J. Autian 2:00 p.m.-3. A Quantitative Evaluation of the Heat Stabilizing Properties of Organotin Compounds in Rigid Polyvinyl Chloride Using Differential Thermal Analysis-R.K. O'Leary, J. Foy, W.L Guess and J. Autian 2:15 p.m.-4. A Comparative Study of the Alternating and Direct Current Polarography of Several c,. ' -3-Ketosteroids-James L. Spahr and Adelbert M. Knevel 2:30 p.m.-5. Assay of Methenamine Mandelate and Its Pharmaceutical Preparations by Direct Cerimetric Titration-Lester Chafetz and Charles A. Gaglia, Jr. 2:45 p.m.-6. The Automated Determination of Thiamine in Both Simple Solutions and Complex Preparations-A.J. Khoury and LJ. Cali 3:00 p.m.-7. Separation and Quantitative Determination of Adrenaline Using Thin Layer Chromatography-N.H. Choulis 3:15 p.m.-S. Molecular Interaction of Stereoisomers When in Solid State-N.H. Chou lis 3:30 p.m.-9. The Fluorometric Investigation of Certain Aralkylamines-W.E. Lange and J.M. Theodore, Jr. 3:45 p.m.-IO. A Study of Indicators and EDTA Solutions in the Assay of Calcium Salts-Albert C. Smith 4:00 p.m.-H. Quantitative Analysis of Some Pharmaceutical Powders by Water Absorption Technic-LR. Ciufo and R.M. Cox 4:15 p.m.-12. Determination of in Vitro Release Rates of Sustained Action Preparations by Paper Chromatography and Electrophoresis-H. Schriftman
third session Thursday, April 28, 9:00 a.m.-AdolphUS, Parlor A Presiding-Carl Rehm and John Wind heuser 9:00 a.m.-13. Chemi stry of the Lavine Method for Determining Methionine. Mechanism of Reversible Oxidation with lodineK.H. Gensch and T. Higuchi 9:15 a.m.-14. Ion Pair Extraction of Pharmaceutical Amines . Role of Dipolar Solvating Agents in Extraction of Dextromethorphan-T. Higuchi, A. Hurwitz, A. Michaelis and T. Tan
economics and administrative science Chairman-Joseph D. McEvilla Chairman -elect-Robert V. Evanson Vice Chairman-Richard L. Hull Secretary-Robert E. Abrams
fi rst session Tuesday, April 26, 2:00 p.m.-Baker, Terrace Room Academy section chairman-(Ieft to right, above) Leon Lachman, industrial pharmacy; Taito Soine, medicinal chemistry, and Joseph D. McEvilla, economics and administrative science .
Symposium-Drugs and Drug Products Moderator-George P. Hager 1. 2.
Academy section secretaries-(Ieft to right, below) Earl A. Kimes, industrial pharmacy; Eugene C. Jorgensen, medicinal chemistry , and Robert E. Abrams, economics and administrative science.
3.
A Drug Becomes a Drug Product-Jack Cooper, CIBA Pharmaceutical Company Generic Equivalence-A Second Look-Max S. Sadove, MD, University of Illinois, College of Med icine Drug Products for the Great Society-Martin Buchalter, Division of Public Welfare, New Jersey State Department of Insitutions and Agencies
second session-business Tuesday, April 26, 4:00 p.m.-Baker, Terrace Room
industrial pharmacy 9:30 a.m.-15. Ion Pair Extraction of Pharmaceutical Amines II. Extraction Profile of Chlorpheniramine-T. Higuchi, K. Kato, A. Michaelis and Diane Yamamoto 9:45 a.m.-16. Evaluation of a Spectropolarimetric-Penicillinase Method for Determining the Activity of Penicillin-T. Higuchi and C.E. Rasmussen 10:00 a.m.-17. Near-Infrared Spectroscopy of Amine SaltsJoseph E. Sinsheimer and Anne M. Keuhnelian 10:15 a.m.-18. Evaluation of Methods for Quenching Correction in Liquid Scintillation Counting of Carbon-14 in Tissue SamplesS. Riegelman and M.K. Asghar 10:30 a.m.-19. The Formation of Acetylcodeine Aspirin and Codeine-A.L. Jacobs, A.E. Dilatush, S. Weinstein and J.J. Windheuser 10:45 a.m.- -20. Nuclear Magnetic Resonance Spectra of AminesJ.E. Zarembo, W.E. Thompson, R.J. Warren and I.B. Eisdorfer 11:00 a.m.-21. Characterization of the Epoxidation Product of cis-4-(p-Chlorophenyl)-5-Cyanocyclohexene from NMR of Derivatives-David B. Roll and Alain C. Huitric 11:15 a.m.-22. The Detection of Some Form i minoesters and the Measurement of Their Rates of Formation Using NMR-Jay Nematollahi and L. Dallas Tuck 11:30 a.m.-23. A Quantum Chemical Study of Sydnones Using the w-Huckel Technic-L.B. Kier and E.B. Roche
Chairman-Leon Lachman Chairman -elect-Edward Hanus Vice Chairman-Herbert Lieberman Secretary-Earl A. Kimes
fi rst session Monday, April 25, 9:00 a.m.-DMA 300 Symposium-Plastic Containers for Pharmaceutical Products Presiding-John Autian
1.
Quality Manufacture of Plastic Pharmaceutical ContainersJules Pinsky 2. Toxicological Considerations in the Selection of Plastic Containers-Wallace L. Guess 3. A Study of Pharmaceuticals Stored i n Plastic Containers, U .S. Army Testing Program, Interim Report- H.M. Beal, P.J. Jannke and J. Pinsky 4. Discussion-speakers plus Richard W. Pecina
second session Monday, April 25, 1:30 p.m.-DMA 300
fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Cactus Room Symposium-The Application of Analytical Technics to the Stability of Drugs (Drug Standards, Analysis and Control and Scientific Sections Joint Symposium)
Symposium-New Pharmaceutical Packaging Equipment and Materials
and
Presiding-Roy Kuramoto Equipment 1. 2.
Chairman-Jonas Carol 1:30 p.m.-1. Application of Thin Layer Chromatography and Radioisotope Technics to Stability Studies-J.P. Comer, Eli Lilly and Company 2:00 p.m.-2. Applications of Gas-Liquid Chromatography to the Stability Testing of Drugs-C.R. Rhem , CI BA Pharmaceutical Company 2:30 p.m.-3. Functional Group Approach to Studies of Drug Stability-A.A. Forist, Upjohn Company 3:00 p.m.-4. Interrelation of Analytical Technic Applied to Stability Studies and Studies on Drug Homogeneity-D.H. Szulczeski, Parke, Davis & Co . 3:30 p.m.-Discussion of papers 4:00 p.m.-Panel discussion-E. Meyers, Food and Drug Ad ministration; T. Higuchi, University of Wisconsin School of Pharmacy; M. Auerbach, Sterling Winthrop Research Institute, and L. Chatten, University of Alberta (Canada) School of Pharmacy
Manufacturing
3. 4.
Production Experience with Glatt Fluid Bed Dryers-R.A. Hill and R. Cilento The Evaluation of the Deltapress, A Precompression Tablet Press-Daniel Pasquale Vial Sterilization and Filling on a Continuous Basis-Charles Riffkin Evaluation of the Zanasi Automatic Capsule Filler-L. Everett Stoyle, Jr.
Materials 1. 2.
Direct Compression Formulating-R. Cohn, R. Nessel and G. Reier The Formulation of Ion Exchange Resin Adsorbates in Topical Products-J.B. Ward and G.J. Sperandio
Packaging or Packaging Components 1. 2.
A Simple Data Retrieval System for Package ComponentsW.G. McDowell Recent Packaging Developments for Pharmaceutical AerosolsJohn J. Sciarra
Vol. NS6, No.3, March 1966
123
third session Tuesday, April 26, 9:00 a.m.-Baker, Crystal Ballroom Symposium-Present Concepts of the Biopharmaceutics of Oral Dosage Forms
4.
Th e Description and Evaluation of an In strumented Pilot Plant Lyophilizer and Its Versatility in Developing and Programming Production Cycles-Patrick P. DeLuca
eighth session
Presidin g-Martin Katz
Friday, April 29, 9:00 a.m.-Adolphus, Cactus Room
1.
Presiding-Arlyn Kinkel and Hyman Mitchner
2. 3.
4.
In Vitro Evalu ation of Dosage Form s-John H. Wood Design and Data Analy sis of Biopharmaceutical Studies in Man-John G. Wagner . Correlation of Gastrointestinal Ab so rptions and In Vitro DIssolution Kinetics of Drugs Contained in Oral Solid Dosa ge Forms-Gerhard Levy Discussion-speakers plus Ruth Levine and Anthony Glazko
fourth session-luncheon Tuesday, April 26, 12:00 noon-Baker, Lounge Address-Irving Marcus, superintendent of the chemical examining corps., U .S. Patent office
fifth session-business Tuesday, April26, 2:00 p.m.-Baker, Crystal Ballroom 1.
Call to order
2. Chairman ' s address-Leon Lachman 3. 4.
5. 6. 7. B. 9.
Secretary-treasurer's report-Earl A. Kimes Committee reports A. Program-Herbert Lieberman B . Membership-Edward Hanus C. National Committee on Regional Meetings-Roy Kuramoto D. Bylaws-Carl Lintner E. Acade m y-Jack Cooper F. Audio- vis ual-George Schneller G. Education-Stuart Eriksen H. Screening papers-Arnold Marcus I. Resolutions-Walter Charnicki Unfin i shed business New business Report of nominatin g committee-Jim McDavid Election and installation of officers Adjournment
sixth session Thursday, April 28, 9:00 a.m.-Adolphus, Roof Garden Presiding-Arnold Marcus and Harold Wolkoff 9:00 a.m.-I. Mechanism of Action of Starch as a Tablet Disinte· gra nt I. Preliminary Report. Factors that Affect Swelling of Starch Gra ins at 37°C-James T. Ingram and Werner Lowenthal 9:15 a.m.-2. Adhesion Tension Determinations for Evaluatin g Binders in Tabletting-J.K.J. Lim, H.O. Thompson and C. Pian· tadosi 9:30 a.m.-3. Exp erience in the Development of Directly Compressible Tablets Containing Potassium Chloride-Jack Lazarus and Leon Lachman 9:45 a.m.-4. Stability of Certified Dyes and Tablets III.-F.W. Goodhart, H.A. Lieberman, D.S. Mody and F.C. Ninger 10:00 a.m.-5. Further Studies on the Stability of FD&C Blue No.2 in Aqueous Solutions-C. Allen Brownley, Jr. and Leon Lachman 10:15 a.m.-6. A Controlled Release Dosage Form for Oral Administration-H.E. Huber, L.B. Dale and G.L. Christenson 10:30 a.m.-7. Sustained Release Plastic Matrix Dose Form I. Effect of External Factors on Drug Release-C.J. Endicott, J.D. Buddenhagen, P.W. Romig and R.H. Schleif 10:45 a.m.-B. Powder Flow Studies I. Instrumentation-Gerald Gold, Ronald N. Duvall and Blaze T. Palermo
seventh session Thursday, April 28, 1:00 p.m.-Adolphus, Roof Garden Presiding-Walter Charnicki
1. 2. 3.
124
Development and Technology of a Semi-Automated Continuous Extrusion Process for the Preparation of a Tablet GranulationH.T. Snyder, J.V. Battista and J. Michelson Rotary Tablet Machine Instrumentation-P.E. Wray, J.G. Vin· cent, F.W. Moller and G.J. Jackson The Formulation and Physical Properties of Aerosol Foams Intended for Top ica l Application of Medicinals-William A. Strickland, Jr.
Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION
9:00 a.m.-9. Powder Flow Studies II. Glidants-Gerald Gold, Ronald N. Duvall and Blaze T. Palermo 9:15 a.m.-10. Increased Hydrophilic Capacity of Polyethylene Glycol Ointment USP XVI-W. Chandranondnaiwinit a nd B. Sommers 9:30 a.m.-11. A Study of the Compressibility of Pharmaceutical Solids I. Instrumentation Employed and Preliminary Results Obtained-Jacob Varsano and Leon Lachman 9:45 a.m.-12. The Effects of Shear Processi ng and Thermal Exposure on the Viscosity-Stability of Polymer Solutions-D.R. Powell, J. Swarbrick and G.S. Banker .. 10:00 a.m.-B. Micromeritics of Granular Pharmaceutical Solids II. Factors Involved in the Sieving of Pharmaceutical GranulesDale E. Fonner, Gilbert S. Banker and James Swarbrick 10:15 a.m.-14 . Lined and Unlined Rubber Stoppers for Multiple Dose Vial Solutions II. Effect of Teflon Linin g on Preservati ve Sorption and Leaching of Extractives-Leon Lachman, Wayne A. Pauli Pravin B. Sheth and Miriam Pagliery 10:30 ~.m.-15. Stability Data Evaluation: Graphic Statistical Analysi s-L.L. Kaplan
medicinal chemistry Chairman-Taito O. Soine Chairman-elect-W. Lewis Nobles Vice Chairman-Irwin J. Pachter Secretary-Eugene C. Jorgensen
first session Monday, April 25, 9:00 a.m.-DMA 303 Pre siding-Lemont B. Kier and Ole Gisvold 9:00 a.m.-I. A Comparison of the Antimicrobial Prope rties of 5a· and 5/l-4-Azacholestanes-N.J. Doorenbos, K.R. Scott and L.M. Rice 9:15 a.m.-2. Hypoiodite Oxidation of 3a-Bromo and 3a-Chloro2/l-Hydroxy-5a-Androstan·17-0ne-G.W. Adelstein and R.E. Counsell 9:30 a.m.-3. A Novel Oxazole Synthesis-Roger Ketcham and Arnold Martin 9:45 a.m.-4. Basically Substituted Dioxolanes and Dioxane sH.V. Maulding, Jr. and Ole Gisvold 10:00 a.m.-5. The Preparation of Mixed Glycol Acetal Carbamates by Transacetalation of Certain Di- and Trihydric Alcohols-R.K. Rauch, Fred T. Semeniuk and Claude Piantadosi 10:15 a.m.-6. Amides, Esters of Heptamethylene and Octamethylene Moiety-Heino A. Luts and Jerome F. Grattan 10:30 a.m.-7. The Synthesis of Labeled Isomers of Dichlorodi· phenyldichloroethane (DDD)-R.E. Willette and R.E. Counsell .. 10:45 a.m.-B. Certain Esters of 1-, 2-, 3-Methyl-2-HydroxyqUinollzl' dines as Potential Local Anesthetic Agents-M.A. Zoglio, T .O. Soine and E.G. Rippie 11:00 a.m.-9. Anticonvulsants III. Alkyl Esters of 4-Bromo-2Sulfamoylbenzoic Acid and 4-Chloro·2-Sulfamoylbenzoic AcidGlenn H. Hamor and Bernard L. Reavlin 11:15 a.m.-10. The Synthesis of Some Disubstituted Cyanoacetamides as Potential Anticonvulsants-Herbert F. Schwartz II, Lee F. Worrell and Jaime N. Delgado 11:30 a.m.-11 . Structure·Activity Relationships among Some NAlkyl- and N-Dialkyl-2,2-Dialkylcyanoacetamides, Including 2Cyanoacyl-Piperidines, Pyrrolidines and Morpholines-Herbert F. Schwartz II, Robert G. Brown and Jaime N. Delgado 11:45 a.m.-12. Synthesis of Aldoxime Analogs of Arecholine as Cholinesterase Reactivators-J.N. Wells, J.N. Davisson and G.K.W. Vim
second session Monday, April 25, 1:30 p.m.-DMA 303 Presiding-Raymond E. Counsell and Eugene C. Jorgensen 1:30 p.m.-B: The Isopropylidene Derivatives of Digitoxin, Digoxin and Ouabain-O. Gisvold
pharmaceutical technology Chairman-Edward J. Rowe Chairman-elect-G.S. Banker Vice Chairman-F.P. Cosgrove Secretary-Ben F. Cooper
fi rst session Monday, April 25, 1:30 p.m.-DMA 301 Presiding-Edward J. Rowe Academy section chairman-(Ieft to right, above) Joseph P. Buckley, pharmacology and biochemistry; Arthur E. Schwarting, pharmacognosy and natural products, and Edward J. Rowe, pharmaceutical technology.
Academy section secretaries-(Ieft to right, below) Allan Conney, pharmacology and biochemistry; Jack L. Beal, pharmacognosy and natural products, and Ben F. Cooper, pharmaceutical technology.
1:30 p.m.-I. Mechanism of Action of Starch as a Disintegrating Agent in Aspirin Tablets-N.R. Patel and R.E. Hopponen 1:45 p.m.-2. Inositol as a New Base for Chewable Tablets-S.S. Nasir and LO. Wilken, Jr. 2:00 p.m.-3. Particle Size Distribution and Hopper Flow RatesE.D. Summer and H.O. Thompson 2:15 p.m.-4. Dye-Polyethylene Glycol 6000 Interactions in Film Coating Solutions and Their Effect on Color Uniformity-D.G. Bhatia, T.D. Sokoloski and V.N. Bhatia 2:30 p.m.-5. A Proposed Method of Testing Aerosol Preparations Using Chetomium Globosum as the Test Organism-J.W. Blasechi, Jr. and M. lannarone 2:45 p.m.-Business meeting A. Chairman's opening remarks-Edward J. Rowe B. Secretary-treasurer's report-Ben F. Cooper C. Appointment of committees D. Organizational structure of Academy of Pharma ceutical Sciences-discussion
second session Tuesday, April 26, 2:30 p.m.-Adolphus, French Roo m Presiding-Ben F. Cooper 1:45 p.m.-l4. Synthesis and Biological Evaluation of Analogs of Angiotensin II-E.C. Jorgensen and W. Patton 2:00 p.m.-l5. Thyroxine Analogs. 3,5-Thioalkyl and Thioaryl Thyronines-E.C. Jorgensen, R.O. Muhlhauser and R.A. Wiley 2:15 p.m.-l6. N-Ethyltryptamine Derivatives Related to Reserpine and Lysergic Acid-S. Sklar, K.A. Nieforth and M.H. Malone 2:30 p.m.-17. Spectrophotometric and Chemical Studies of 5Mercaptouracil , 5-Mercaptodeoxyuridine and Their S-Substituted Derivatives-T.J. Bardos and T.I. Kalman 2:45 p.m.-l8. Enzyme Inhibitors XIV. The Syntheses of Some 9-(m-Substituted Benzyl)-6-Substituted Purines as Inhibitors of Adenosine Deaminase-Howard J. Schaeffer and R.N. Johnson 3:00 p.m.-l9. Phosphorus-Nitrogen Compounds V. Some Gua nidine and 2-Aminopyrimidine Derivatives-L.A. Cates and N.M. Ferguson 3:15 p.m.-20. Phosphorus-Nitrogen Compounds VI. Some Phenethylamine Derivatives-LA. Cates, W.H. Lawrence and R.J. McClain 3:30 p.m.-21. Synthesis of N,N '-Haloacyl Analogs of p ,p ' -Oxydianiline as Potential Antineoplastic Agents-W.O. Roll 3:45 p.m.-22. Synthesis of 4-Substituted 7-Methylpyrrolo [2,3-d] Pyrimidines-Richard H. Hammer 4:00 p.m.-23. 5a-Aryl-6-Methylthymines as Potential Antimetabolites-J.H. Burckhalter and James L Brannon 4:15 p.m.-24. The Constituents of the Volatile Oil of Pycnanthemum Albescens-John T. Goorley
2:30 p.m.-6. Flavor Specialization-Fred Wesley 2:45 p.m.-7. A Rheological Evaluation of Lipophilic Suspending Agents. I. Dimethyl Dialkyl Ammonium Hectorite-C.T. Lesshafft, Jr. 3:00 p.m.-8. The Effect of Ultrasound on the Particle Size of Suspensions-M.A. Sheikh, J.C. Price and R.J. Gerraughty 3:15 p.m.-9. Drug Release Determination from Ointment Bases Using a Microbiological "Agar-Tube " Method-N.F. Billups 3:30 p.m.-lO. Dialysis Cell Method of Measuring Drug Release from Ointment Bases-J.M. Howze and N.F. Billups 3:45 p.m.-Business meeting continued A. Chairman'S remarks-Edward J. Rowe B. Committee reports C. Unfinished business D. Old business E. New business F. Report of nominating committee G. Adjournment
th i rd session Thursday, April 28, 1:30 p.m.-Adolphus, Grand Ballroom Pharmaceutical Technology and Pharmacology and Biochemistry Sections' Symposium-Psychopharmacology (see pharmacology and biochemistry for program)
third session-business Monday, April 25, 7:00 p.m.-Adolphus, Civic Room II
pharmacognosy and natural products
social Monday, April 25, 8:00 p.m.-Adolphus, Civic Room II
Chairman-Arthur E. Schwarting Chairman-elect-Varro E. Tyler, Jr. Vice Chairman-Gordon H. Svoboda Secretary-Jack L. Beal
fou rth session
fi rst session
Tuesday, April 26, 9:00 a.m.-Baker, Terrace Room
Monday, April 25, 9:00 a.m.-DMA 301
Symposium-Advances in Natural Product Chemistry
Presiding-Wilbert G. Walter and Ralph N. Blomster
(Medicinal Chemistry and Scientific Sections Joint Symposium)
Chairman-Howard J. Schaeffer 1.
Biosynthesis of Alkaloids-Edward Leete, University of Minnesota 2. RecentAdvances in the Chemistry of Naturally-Occurring Tumor Inhibitors-S. Morris Kupchan, University of Wisconsin 3. Solid-Phase Peptide Synthesis-Bruce Merrifield, Rockefeller Institute
9:00 a.m.-I. Alkaloids of the Rutaceae I.-Gordon H. Svoboda and Gerald A. Poore 9:15 a.m.-2. Cytotoxicity and Antitumor Activity of North Dakota Plants Part I. In Vitro Studies. I-A. Muni, W.H. Bhatti, LJ . Schermeister and M.C. Vincent 9:30 a.m.-3. Neriifolin: An Antitumor Agent from Thevefia Peruviana (Apocynaceae)-E. Bianchi, M.E. Caldwell and J.R. Cole 9:45 a.m.-4. Isolation of Antitumor Fractions of Abies Concolor (Pinaceae)-A. Ulubelen, M.E. Caldwell and J.R. Cole
Vol. NS6, No.3, March 1966
125
Devoted to the fashion industry, the Apparel Mart is a center of attraction in Dallas. In this four-story structure housing 1,250 display rooms along four miles of corridors, the ladies will be entertained at their annual fashion show and luncheon. The Great Hall of the Apparel Mart will be used for the show. Special "pop" concerts also are given in the Hall by the Dallas Symphony Orchestra .
10:00 a.m.-5. Kilmer Prize paper 10:15 a.m.-6. Purification of Antibiotics-Michael Telepchak (APhA science fair winner) 10:30 a.m.-7. The Role of Ascorbic Acid Oxidase in the Hyoscyamine-Scopolamine Ratio in Datura Innoxia Miller-Helen Louise Rowland and Melvin R. Gibson 10:45 a.m.-8. Morning Glory Tissue Cultures: Growth and Examination for Indole Alkaloids-E.J. Staba and P. Laursen 11:00 a.m.-9. Isolation and Identification of Cantharidin in Epicauta Pestifera-W.G. Walter and J.F. Cole 11:15 a.m.-lO. Phytochemical I nvestigation I. Glycosides in Phytolacca Americana-W.G. Walter and H.M. Crosby 11:30 a.m.-ll. Studies on the Toxicity of Wisteria Seed-C. Dwayne Ogzewalla
second session Tuesday, April 26, 2:30 p.m.-Baker, Fiesta Room Presiding-Arthur E. Schwarting and Jack L. Beal 2:30 p.m.-12. Isolation of Two Bisbenzylisoquinoline Alkaloids from the Rhizomes and Roots of Xanthorhiza SimplicissimaJ.E. Knapp, F.T. Hussein, J.L. Beal, R.W. Doskotch and T. Tomimatsu 2:45 p.m.-l3. The Isolation and Identification of Three Alkaloids from the Bark of Xanthoxylum Elephantiasis Macf-A.T. Awad, J.L. Beal, S.K. Talapatra and M.P. Cava 3:00 p.m.-14. Occurrence of Amanita Toxins in American Collections of Deadly Amanitas-V.E. Tyler, Jr_, R.G. Benedict, L.R. Brady and J.E. Robbers 3:15 p.m.-15. Catharanthus Alkaloids X. Isolation of Lanceine, Ammocalline, Vinosidine and Catharine from C. Lanceus-R.N. Blomster, N.R. Farnsworth, D.J. Abraham, A.J. Sharkey, Jr. and H.H.S. Fong 3:30 p.m.-16. Catharanthus Alkaloids XI. Biological Effects of Fractions and Alkaloids Separated from C. Lanceus-N.R. Farnsworth, R.N. Blomster and J.P. Buckley 3:45 p.m.-Business meeting
pharmacology and biochemistry Chairman-Joseph P. Buckley Chairman-elect-J. William Keating Vice Chairman-Ewart A. Swinyard Secretary-Allan Conney
fi rst session Monday, April 25, 9:00 a.m.-DMA 302 Presiding-Ewart A. Swinyard and Vernon A. Green 9:00 a.m.-I. Attempts at Induced Agranulocytosis in Rats Using Dipyrone-N.M. Ferguson and Arthur F. Novak 9:15 a.m.-2. A New Treatment for Glutethimide IntoxicationGeorge G. Johnston, W.L. Guess and J. Autian
126
Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION
9:30 a.m.-3. Hepatic Toxicity of a Series of Organotin Compounds -David Calley, W.L. Guess and J. Autian 9:45 a.m.-4. Growth Inhibition of Mammalian Cell Cultures by Plastic Materials-S.A. Rosenbluth, W.L. Guess and J. Autian 10:00 a.m.-5. Antagonism of Convulsive and Lethal Effects Induced by Propoxyphene-R.E. Fiut, A.L. Picchioni, L. Chin 10:15 a.m.-6. Evaluation of Oral Dilution as a First Aid Measure in Poisoning-M.L. Henderson, L. Chin and A.L. Picchioni 10:30 a.m.-7. The Effect of Chronic Nortriptyline Pretreatment on the Acute Toxicity of Various Medicinal Agents in Rats-D.B. Meyers, D.O. Kanyuck and R.C. Anderson 10:45 a.m.-8. Chronic Effects of Thyroxine and Pargyline in RatsA.B. Mendillo, A.M. Guarino and J.J. DeFeo 11:00 a.m.-9. Automated Nephelometric Determination of Rat Liver Glycogen in Adrenal Steroid Bioassays-W.F. Beyer 11:15 a.m.-lO. Alterations in Hyaluronidase Activity and Other Effects of Prolonged Heat Exposure in the Rat-M.M. Clay and M.W. Adler 11:30 a.m.-ll. A Survey of Tetracycline Deposition in the Artery of the Newborn-D.M. Stuart and M.M. Mallin 11:45 a.m.-lla . A Preliminary Report on the in Vitro Antimicrobial Activity of Neomycin Undecylenate Cream on Common Skin Pathogens-Chester F. Koda and Joseph P. Miale
second session Monday, April 25, 1:30 p.m.-DMA 302 Presiding-Nathan Watzman and Harold H. Wolf 1:30 p.m.-12. Antagonism of Free Fatty Acid Release from Rat Epididymal Fat Tissue by Desmethylimipramine-K.L. Finger and J.G. Page 1:45 p.m.-l3. Interaction of Various Phenylethylamines with the Adrenergic-Adipose Tissue, Receptor System, in Vitro-K.F. Finger and D.R. Feller 2:00 p.m.-14. The Effect of Hypothermia on Chlorpromazine Induced Bradycardia and Hypotension in the Rat-K.F. Finger, R.L. Cavanagh and E.E. Moog 2:15 p.m.-15. The Utility of Two Convulsant Technics as Indicators ofCNS Excitability-H.H. Wolf and G.A. Stock, Jr. 2:30 p.m.-16. The Effects of Environmental Temperature on the LD50 of Some CNS Stimulants-J.A. Hall, R.B. Nelson and A.I. Edlin 2:45 p.m.-17. Comparison of Different Photobeam Arrangements for Measuring Spontaneous Activity of Mice-N. Watzman, H. Barry, III, W.J. Kinnard, Jr. and J.P. Buckley 3:00 p.m.-18. Behavioral Effects of Oral Compared with Intraperitoneal Doses of Chlorpromazine-H. Barry, III, N. Watzman, J.P. Buckley and W.J. Kinnard, Jr. 3:15 p.m.-19. The Effect of Some Psychotropic Agents on Peripheral Nerve Conduction Rate-Jack K. Pruett and Byron B. Williams 3:30 p.m.-20.' The Effects of Steroids and LSD on the Oxygen Consumption of Rat Brain Homogenates-V.A. Green and T.M. Glenn
3:45 p.m.-21. A Study of the I nteractions of Steroids, Lysergic Acid Diethylamide (LSD), Serotonin (5-HT) and I proniazid on Hexobarbital-Induced Narcosis-T.M. Glenn and V.A. Green 4:00 p.m.-22. Effect of Diphenylhydantoin on Hexobarbital Sleep Time in Mice and Rats-M. Tannhauser, J.W. Kemp, E.A. Swinyard and Louis S. Goodman 4:15 p.m.-23. Actions of Sydnones on Gamma-Aminobutyric Acid Levels in Mouse Brain-L.E. Fox
11:00 a.m.-32. Synthesis of N-Methyl C14 Atropine-T.E. Eling, G.C. Schmidt, J.C. Drach and H.C. Shirkey 11:15 a.m.-33. Preliminary Evidence for the Existence of an Atropine-Degrading Enzyme in Goat Serum-R.G. Miller, G.C. Schmidt and H.C. Shirkey 11:30 a.m.-34. Effects of D-Panthenol Enrichment on Subsequent Drug Action in Smooth Muscle and Skeletal Muscle of RodentsJ.W. Kosh and R.G. Brown 11:45 a.m.-35. Characterizations of the Action of ImipramineC.D. Ross and R.G. Brown
third session Thursday, April 28, 9:00 a.m.-Adolphus, Danish Room Presiding-William J. Kinnard and Marvin H. Malone
9:00 a.m.-24. Desoxycholic Acid Enhancement of Reserpine's Blepharoptotic Activity-M.H. Malone, H.I. Hochman and K.A. Nieforth 9:15 a.m.-25. The Radioautographic Measurement of Tritiated Thymidine Uptake by a Malignant Cell Line on Exposure to Certain Glucocorticoids I. Adaptation of Radioautographic TechnicSr. M. Consolatrix Jakschik, SAC, Denise M. Eno and C. Kaplan 9:30 a.m.-26. The Radioautographic Measurement of Tritiated Thymidine Uptake by a Malignant Cell Line on Exposure to Certain Glucocorticoids II. Effect on Cell Proliferation-Sr. M. Consolatrix Jakschik, SAC, Denise M. Eno and C. Kaplan 9:45 a.m.-27. A New Technic for Evaluating Anti-Ulcer Drugs; Gastric Erosions Produced by Insulin Hypoglycemia-W.G. Groves, P. Setler and D. Arbakov 10:00 a.m.-28. The Evaluation of Antispasmodic and Related Activity in the Intact Dog II.- N. Katz and H.J. Jenkins 10:15 a.m.-29. Metabolism of dl-Amphetamine Sulfate in the Rat-A.A. Noujaim, P.L. Ziemer and J.E. Christian 10:30 a.m.-3D. Effects of Estradiol and Progesterone on the Metabolism of Chlorpromazine-T.S. Miya, E.H. Adams and R. Saunders 10:45 a.m.-31. Accelerated Metabolism of Ethanol in the RatElliot Spector and John F. Reinhard
fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Grand Ballroom Symposium-Psychopharmacology (Pharmacology and Biochemistry and Pharmaceutical Technology Sections Joint Symposium)
Chairman-Joseph P. Buckley 1. 2. 3. 4. 5. 6.
Introductory Remarks-Joseph P. Buckley, University of Pittsburgh school of pharmacy Biochemical and Physiological Basis of Mental DiseaseBernard B. Brodie, National Heart Institute Chemo-Pharmacologic Approaches to the Development of Psychotropic Drugs-John H. Biel, Aldrich Chemical Company Neuropharmacologic Evaluation of Drugs Used in PsychiatryDavid H. Tedeschi, Smith Kline & French Laboratories Initial Preclinical Screening in Psychopharmacology-William J. Kinnard, Jr., University of Pittsburgh school of pharmacy Clinical Efficacy of Psychopharmacological Agents-Leo E. Hollister, MD, Veterans Administration Hospital
fifth session-business Friday, April 29, 10:00 a.m.-Adolphus, Parlor A
section on historical pharmacy
12:00 noon-B. Historical Sketch of the Pharmaceutical Industry in Puerto Rico-Luis Torres Diaz
Chairman-Norman H. Franke Vice Chairman-Herbert C. Raubenheimer Secretary-Esther Jane Wood Hall Delegates to the House of Delegates-George W. Grider and George Osborne
second session
fi rst session
Presiding-Norman H. Franke, chairman
Monday, April 25, 9:00 a.m.-DMA 200 Presiding-Norman H. Franke, chairman
9:00 a.m.-I.
Business session A. B. C. D.
E.
Tuesday, April 26, 2:00 p.m.-DMA 200
Call to order Chairman's address-Norman H. Franke Secretary's report-Esther Jane Wood Hall Appointment of committees Presentation of papers
9:15 a.m.-2. Pharmacy One Hundred Years Ago-O.L. Campbell and C.L. Huyck 9:30 a.m.-3. A Pioneer Drug Store in Vernon, Texas-Edwin S. Malone, III 9:45 a.m.-4. Pharmacy and Pharmacists in Colonial Boston, Massachusetts, Part One- H.C. Raubenheimer 10:00 a.m.-5. John Bull's Medicine-William H. Helfand 10:15 a.m.-6. The New York Branch of the American Pharmaceutical Association-Frank J. Pokorny 10:30 a.m.-7. Philip Charles Candidus: Pioneer Alabama Pharmacist-Lela Irwin Legare 10:45 a.m.-8. Rough and Ready Research-1887 Style-George A. Bender 11:00 a.m.-9. History of the Development of Fair Trade-Norman A. Campbell 11:15 a.m.-lO. The Doll Nina-M.L. Neuroth 11:30 a.m.-ll. Interesting Facets of Medico-pharmaceutical Conditions in the Confederacy-Norman H. Franke 11:45 a.m.-12. Pharmacy-A Stable Profession-Laurence D. Lockie
2:00 p.m.-14. The Early Years of Ohio Northern University College of Pharmacy, V-C.O. Lee 2:15 p.m.-15. History of Xavier University's College of Pharmacy-Y.A. Soucy and C.L. Huyck 2:30 p.m.-16. Pharmacy and Pharmacists in Colonial Boston, Massachusetts, Part Two-H.C. Raubenheimer 2:45 p.m.-17. The Texas State Historical Survey Committee Medallion Pharmacy in Jefferson, Texas and SurroundingsMrs. Dan Lester 3:00 p.m.-18. The Founding of the American College of Apothecaries-E.W. Stieb 3:15 p.m.-19. Rise and Demise of the Spanish Edition of the U.S. Pharmacopeia-Nydia M. King 3:30 p.m.-20. Medicine and Pharmacy in the Torah and Talmud: I. Birth Control and Contraception-Mark M. Lukens 3:40 p.m.-21. The Pharmaceutical Exhibition at the SmithsonianSami K. Hamarneh 3:50 p.m.-22. The Restoration of a New Jersey Pharmacy-1890John L. Voigt 4:00 p.m.-23. Pharmacy and Medicine Aboard the New England Whaleships-George E. Osborne and Arthur G. Lipman 4:10 p.m.-24. The First Day-October 26, l886-George A. Bender 4:20 p.m.-25. Early Years of Pharmacy Organization in Dallas, Texas-Esther Jane Wood Hall 4:30 p.m.-26. Business session A. Unfinished business B. Report of committees C. Election and installation of officers D. Adjournment Vol. NS6, No.3, March 1966
121
3.
4. 5.
Call to order Officers' reports Pharmaceutical Services to Nursing Homes A. Provisions for Pharmaceutical Services in Small Minnesota Hospitals-Hugh F. Kabat B. Address-Alfred Ercolano, executive secretary, American Nursing Home Association C. Address-Donald P. Conwell, MD, USPHS D. Address-Henry H. Henley, president, McKesson and Robbins E. Pharmaceutical Service to Nursing Homes-premier showing of filmstrip Five workshop sessions S{Jmmary and workshop reports
A cad em y pre s idents-Takeru Higuchi (left), pharmaceutical sciences, and Raymond L. Dunn, general practice of pharmacy.
Academy secretaries-Sa m u el W. Gold s t e i n (left), pharmaceutical sciences, and John T. Fay, Jr., general practice of pharmacy.
second session Tuesday, April 26, 9:00 a.m.-DMA Theatre (Meeting jointly with American College of Apothecaries) Public and Professional Communications
1. 2. 3. 4.
Demonstration of Physician Detailing by Pharmacists The Television Image of the Pharmacist Are the American People Being Told Too Much about Drugs? The Use of RPh as part of the Pharmacist's Signature
th i rd session Wednesday, April 27, 9:00 a.m.-Adolphus, Grand Ballroom Aids to Professional Practice
1.
2. 3.
4. 5. 6. 7.
Population and the Prescribing Habits of Physicians-Charles L. Braucher Prescription Pricing and the Professional Fee-Harry A. Smith Problem Prescriptions: Some Analyses for the Practicing Pharmacist-V. Jean Brown New Pharmaceutical Centers-James E. Allen and Emil Martini, Jr. Problems that Occur Commonly in Community Practicepremier showing of film Five workshop sessions Summary and workshop reports
fou rth session Thursday, April 28, 9:00 a.m.-Baker, Crystal Ballroom 1. 2. 3. 4. 5.
Community Pharmacies' Economic Growth Curves-R.W. Hammel A Study of the Purchasing Practices of the Community Pharmacies of the State of Mississippi-B.J. Keller Complete Directions for Prescriptions-Allen J. Brands Prepared Prescription Insurance in Rural Communities-D.N. Hansell Panel: Understanding Public Law 89-97 Moderator-Wallace Werble, editor, F-D-C Reports Panelists Solomon J. Axelrod, MD, University of Michigan school of public health John W. Cashman, director, division of medical care administration, U.S. Public Health Service, Department of Health , Education and Welfare Fred H. Steininger, director, bureau of family services, Welfare Administration, Department of Health, Education and Welfare
fifth session
4.
Over-the-Counter Compounds with Sedative Properties-C.K. Erickson 5. Expectorants and Cough Depressants-R.K. Chalmers 6. Burn and Sunburn Remedies-N.A. Hall 7. Antihistamines and other Allergic Aids-M.H. Weinswig
academy of pharmaceutical sciences President-Takeru Higuchi President· elect-Joseph V. Swintosky Vice President-George P. Hager Pa st President-Jack Cooper Secretary-Samuel W. Goldstein Membership -a t -La rge Representatives-John E. Christian, Howard J. Schaeffer and George H. Schneller
executive committee Sunday, April 24, 3:00 p.m.-DMA 201
business meeting Wednesday, April 27, 9:40 a.m.-Baker, Crystal Ballroom 1. Call to order 2. Reading of communications 3. President's address-Takeru Higuchi 4. Secretary's report-Samuel W. Goldstein 5. Committee reports A. International honors-Takeru Higuchi B. Finance-Jack Cooper C. Membership-George P. Hager D. Sections-Joseph V. Swintosky E. Spheres of interest and organization-Joseph V. Swintosky F. Nominations and elections-Harry B. Kostenbauder G. Bylaws and procedural guides-George H. Schneller H. Patents policy-W. Lewis Nobles I. Smoking and Health-George H. Schneller J . Animal experimentation-Joseph P. Buckley K. Metric system-Joseph V. Swintosky L. Coordination with APhA, ASHP and Academy of General Practice of Pharmacy-Ben F. Cooper M. Symposia and meetings-Louis W. Busse N. Communications-Ralph S. Levi O. Resolutions-John E. Christian 6. New business 7. Adjournment
Thursday, April 28, 2:00 p.m.-Baker, Crystal Ballroom
luncheon
Home Medication in Review
Wednesday, April 27, 12:00 noon-Baker, Lounge
1.
The Public, the Pharmacist and Self Medication-D.A. Knapp 2. Antacids-R.P. Penna 3. The Pharmacist, Acne and Nonprescription Acne MedicationsR.L. Day
120
Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION
executive committee breakfast Friday, April 29, 7:30 a.m.-Adolphus, Parlor C
academy sections scientific Chairman-Robert F. Doerge Chairman -elect-Dale E. Wurster Vice Chairman-Harry B. Kostenbauder ~;ecretary-Rudolph H. Blythe (Papers submitted to the scientific section for presentation at the Dallas meeting were accepted by the secretary of that section but are tIeing presented here by the appropriate "new sections." This has been done in order to expedite the development of the Academy and the several sections representing specific areas of interest.)
breakfast Monday, April 25, 7:30 a.m.-Adolphus, Civic Room II (Executive committee of Academy and presiding officers for sessions on contributed papers.)
first session Tuesday, April 26, 9:00 a.m.-Baker, Crystal Ballroom Industrial Pharmacy and Scientific Sections' Joint SymposiumPresent Concepts of the Biopharmaceutics of Oral Dosage Forms (see industrial pharmacy section for program)
9:45 a.m.-4. Kinetics of Reactions Involved in Penicillin Allergy I. Mechanism of Reaction of Penicillins with Glycine in Alkaline Solution-M.A. Schwartz and Gay-May Wu 10:00 a.m.-5. Utilization of a Model Copolymer to Evaluate the Contribution of Hydrophobic Bonding in Drug Binding-J.B. Nagwekar and H.B. Kostenbauder 10:15 a.m.-6. Interaction of Nonionic Hydrophilic Polymers with Phenols II. Interaction of Phenol, Tannin and Hydroxyphenols with Certain Polyethylene Glycols-B.N. Kabadi and E.R. Hammarlund 10:30 a.m.-7. Diffuse Reflectance Studies of Solid-Solid Interactions II. Interaction of Metallic and Nonmetallic Adjuvants with Anthracene, Prednisone and Hydrochlorothiazide-Michael Bornstein,Ting-fong Chin and John L. Lach 10:45 a.m.-8. Diffuse Reflectance Studies of Solid-Solid Interactions Ill. I nteraction Studies of Oxytetracycline with Metallic and Nonmetallic Adjuvants-John L. Lach and Michael Bornstein 11:00 a.m.-g. Interaction of a Group of Weak Organic Acids and Phenols with Nylon-6-Michael B. Rodell, Wallace L. Guess and John Autian 11:15 a.m.-IO. Permeation Studies of Selected Preservatives through Polyethylene-Mario A. Gonzalez, Wallace L. Guess and John Autian 11:30 a.m.-l1. Sorption and Diffusion Studies of Dicarboxylic Acids with Nylon, 6,6- Part II-R. Kent Stobaugh, H. Berg, W.L. Guess and J. Autian 11:45 a.m.-12. Molecular Orbital Calculations on Sulfonamide Molecules-E.C. Foernzler and A.N. Martin
second session
second session
Monday, April 25, 1:30 p.m.-DMA Room 3A
Tuesday, April 26, 9:00 a.m.-Baker, Terrace Room
Presiding-Louis J. Ravin and John A. Biles
Medicinal Chemistry and Scientific Sections' Joint SymposiumAdvances in Natural Product Chemistry (see section on medicinal chemistry for program)
third session-business Wednesday, April 27, 9:00 a.m.-Baker, Crystal Ballroom 1.
Call to order Chairman's address-Robert F. Doerge Secretary's report-Rudolph H. Blythe Treasurer' s report-Rudolph H. Blythe Committee reports A. Auditing-Louis J. Ravin B. Ebert prize-Howard J. Schaeffer C. Kilmer prize-Melvin R. Gibson D. Physiological testing-Frederick C. Armstrong E. Awards and prizes-E. Roy Hammarlund 6. Unfinished business 7. New business A. Consideration of section dissolution 8. Adjournment
2. 3. 4. 5.
1:30 p.m.-B. The Influence of Ions and Urea on the Surface Activity of Chlorpromazine-Rashmikant M. Patel and George Zografi 1:45 p.m.-14. The Effect of Micelle Formation on the Concen tration Dependence of Surface Tension-Albert J. Flood and L. Dallas Tuck 2:00 p.m.-15. The Effects of Aging and Surfactant Concentration on the Rheology and Droplet Size Distribution of a Nonaqueous Emulsion-R.D. Hamill and R.V. Petersen 2:15 p.m.-16. The Effect of Surfactant Concentration on the Interfacial Viscosity of a Nonaqueous System-R.D. Hamill and R.V. Petersen 2:30 p.m.-17. Kinetics of Metabolism and Urinary Excretion of Dextrorotatory and Levorotatory Mandelic Acid in Humans-J.B. Nagwekar and H.B. Kostenbauder 2:45 p.m.-18. Acetylsalicylic Acid Hydrolysis in Human Blood and Plasma. I. Methodology and in Vitro Studies-P.A. Harris and S. Riegelman
fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Cactus Room Drug Standards, Analysis and Control and Scientific Sections' Joint Symposium-The Appl ication of Analytical Technics to the Stability of Drugs (see section on drug standards, analysis and control for program)
basic pharmaceutics Chairman-Dale E. Wurster Chairman-elect-John A. Biles Vice Chairman-Harry B. Kostenbaudet Secretary-James E. Tingstad
Academy section chairmen-(Ieft to right, above) Robert F. Doerge, scientific; Dale E. Wurster, basic pharmaceutics, and Lloyd C. Miller, drug standards, analysis and control.
Academy section secretaries-(Ieft to right, below) Rudolph H. Blythe, scientific; James E. Tingstad, basic pharmaceutics, and Dale H. Szulcewski, drug standards, analysis and control.
fi rst session Monday, April 25, 9:00 a.m.-DMA Room 3A Presiding-John L. Lach and John Autian 9:00 a.m.-I. Transition Metal Complexes of Substituted Thiouracils-Edward R. Garrett and Dennis J. Weber 9:15 a.m.-2. The Thermodynamics of Chelation by TetracyclinesLeslie Z. Benet and Jere E. Goyan 9:30 a.m.-3 . A Comparison of the Solubility, Spectral and Kinetic Technics for Studying Complex Formation-Joseph A. Mollica, Jr. and Kenneth A. Connors
Vol. NS6, No. 3, March 1966
121
3:00 p.m.-ISa. Theoretical Formulation of Sustained Release Dosage Forms-J.R. Robinson, H. Stelmach and S.P. Eriksen 3:15 p.m.-Business meeting
third session Tuesday, April 26, 2:30 p.m.-Baker, Texas Room Presiding-Edward G. Rippie and David E. Guttman 2:30 p.m.-19. Interaction of Di- and Tri-Carboxylic Acids with Glutaric Anhydride in Aqueous Solution-J.R. Robinson, A.J. Repta and T. Higuchi 2:45 p.m.-20. Interaction of Acetic Anhydride with Citrate Ions in Aqueous Solution-A. J. Repta, J. R. Robinson and T. Higuchi . 3:00 p.m.-2L Catalytic Effect of Copper (II) Ion on th e HydrolYSIS of Some Esters and Amides-A.J. Agren 3:15 p.m.-22. Kinetics of Solvolysis of Various N,N ' -Disubstituted N-Nitrosoureas in Neutral and Alkaline Solution-Edward R. Garrett and Shigeru Goto 3:30 p.m.-23. Kinetics of Solvolysis of Some 3- and 3,4-Substituted Sydnones-Edward R. Garrett and Parimal J. Mehta 3:45 p.m.-24. Kinetics and Mechanisms of Hydrolysis or I-Substituted 6-Amino-2-Thiouracils-Ting-fong Chin, Wen-hung Wu and John L Lach 4:00 p.m.-25. The Hydrolytic Behavior of Riboflavin and Related Isoalloxazines 1. Studies with 9-Methylisoalloxazine-D.A. Wadke and D.E. Guttman 4:15 p.m.-26. The Hydrolytic Decomposition of Sodium Sulfacetamide in Selected Aqueous Systems-Sr. Francis Mary Schleider, OP, D.M. Eno, J.A. Feldman and A.M. Galinsky 4:30 p.m.-27. The Photochemical Formation of Hydrogen Peroxide in White Lotion USP-E.P Guth and Z. Mansour 4:45 p.m.-2S. The Effect of Organic Inhibitors on in Vitro Activity of Several Antacids-H. Stromberg and R.C. Brogle
fou rth session
9:45 a.m.-44. Factors Affecting the Absorption of Riboflavin in Man-Gerhard Levy and W.J. Jusko 10:00 a.m.-45. The Metabolism of C14 Labeled Glutamic and Pyroglutamic Acid in Animals-W.E. Lange and E.F. Carey 10:15 a.m.-46. Effect of pH on the in Vitro Absorption of Flufenamic Acid-Armando J. Aguiar and Richard J. Fifelski 10:30 a.m.-47 _ The Effect of Some Nonionic Surfactants on the Rate of Release of Aminophylline from Suppositories-J.M. Plaxco, Jr. and C.B. Free 10:45 a.m.-4S. In Vivo Pharmacodynamic Evaluation of Oral Dosage Forms by Whole Body Liquid SCintillometry-G. Hecht, J.E. Christian and G.S. Banker 11:00 a.m.-49_ Studies on the Mechanism of Action of Phenolic Disinfectants VII. Factors Affecting Binding of Phenol Derivatives to Micrococcus Lysodeikticus Cells-J. Judis 11:15a.m.- 50. A Mathematical Treatment of Repetitive-Dose Kinetics-King Chiu Kwan, Maurice P. Zirrith, Robert A. Castello and Arnold D. Marcus 11:30 a.m.-5L Effect of Inert Tablet Ingredients on Drug Absorption Part II. Effect of Various Adjuvants on the Dissolution Rate and Intestinal Absorption of Salicylic Acid-Ganga S. Pandey, Leslie Z. Benet, William E. Johnson and V.N. Bhatia 11:45 a.m.-52. A Study of Possible Mutagenic Effects of Gamma Radiation on Antibiotic-Producing Actinomycetes-Ada R. Dogger and James P. Vacik
drug standards, analysis and control Ch airman-Lloyd C. Miller Chairman-elect-Klaus Florey Vice Chairman-William J. Mader Secretary-Dale H. Szulcewski
first session-business Monday, April 25, 9:00a.m.-DMA Room 3B
Thursday, April 28, 9:00 a.m.-Adolphus, Cactus Room Presiding-William I. Higuchi and James E. Tingstad 9:00a.m.-29. Investigation of Factors Controlling Release of Solid Drug Dispersed in Inert Matrices II. Quantitation of ProceduresS.J. Desai, A.P. Simonelli and W.l. Higuchi 9:15 a.m.-30. Release of Drug Dispersed in Inert Matrices 111. Some Cases Involving the Polyethylene Matrix-S.J. Desai, P. Singh, W.I. Higuchi and A.P. Simonelli 9:30 a.m.-3L The Solubility of the Xanthines, Antipyrine and Several Derivatives in Syrup Vehicles-A.N. Paruta and B.B. Sheth 9:45 a.m.-32 . The Solubility of Succinic Acid in Binary Mixtures as a Function of the Dielectric Constant-A.N. Paruta 10:00 a.m .-33 . Solubilization of Gluco-Corticoids by Aqueous Solutions of Triton WR-1339-Witold Saski 10:15 a.m.-34 . Studies of the Crystal Growth Kinetics and Mechanisms of Sulfathiazole and Methylprednisolone in Various Solvents-P.O. Bernardo and W.I. Higuchi 10:30 a.m.-35. Dissolution Rate Behavior of the Polymorphic Forms of Sulfathiazole and Methylprednisolone-P.O. Bernardo, S.C. Mehta and W.I. Higuchi 10:45 a.m.-36 . Heats of Transition of Methylprednisolone and Sulfathiazole by a Differential Thermal Analysis Method-J. Keith Guillory 11:00 a.m.-37. The Influence of the State of Molecular Aggregation on the Enzymic Hydrolysis of Arylsulfate Esters-T.H. Baxter and H.B. Kostenbauder 11:15 a.m.-3S. Studies on the Aggregation of Denatured Proteins 1. Methodology Based on the Multichannel Particle Counter and Analyzer-N.F.H. Ho and W.I. Higuchi 11:30 a.m.-39. Aggregation of Certain Medicinal Amines in Aqueous Solution of Their Salts-B. Farhadieh, E.R. Hammerlund and N.A. Hall 11:45 a.m.-40. Negative Thixotropy in Flocculated Clay Suspensions-J.C. Samyn and W.Y. Jung
fifth session Friday, April 29, 9:00 a.m.-Adolphus, Danish Room Presiding-Theodore D. Sokoloski and James A. Seitz 9:00 a.m.-4L Hemolysis of Erythrocytes by Antibacterial Preservatives III. Influence of Dimethylsulfoxide on the Hemolytic Activity of Phenol-H.C. Ansel and W.F. Leake 9:15 a.m.-42. A Study of the Retention, Excretion and Distribution of 2,3,5-Triiodobenzoic Acid and Its Metabolites in the Rat-R.D. Ice, C.E. Breckinridge, Jr. and J.E. Christian 9:30 a.m.-43. Physicochemical and Physiologic Factors Affecting the Absorption of Warfarin in Man-R.A. O'Reilly, Eino Nelson and Gerhard Levy
122
Journal of the. AMERICAN PHARMACEUTICAL ASSOCIATION
second session Monday, April 25, 1:30 p.m.-DMA Room 3B Presiding-Lester Chafetz and Richard Poe 1:30 p.m.-I. Determination of Aspirin and Barbiturate Combinations by Nonaqueous Titration-Song-Ling Lin and M.l. Blake 1:45 p.m.-2. The Effect of Diester Type Plasticizers on the Differential Thermal Spectrum of a Polyvinyl Chloride System- R.K. O'Leary, J. Foy, W.L Guess and J. Autian 2:00 p.m.-3. A Quantitative Evaluation of the Heat Stabilizing Properties of Organotin Compounds in Rigid Polyvinyl Chloride Using Differential Thermal Analysis-R.K. O'Leary, J. Foy, W.L Guess and J. Autian 2:15 p.m.-4. A Comparative Study of the Alternating and Direct Current Polarography of Several c,. ' -3-Ketosteroids-James L. Spahr and Adelbert M. Knevel 2:30 p.m.-5. Assay of Methenamine Mandelate and Its Pharmaceutical Preparations by Direct Cerimetric Titration-Lester Chafetz and Charles A. Gaglia, Jr. 2:45 p.m.-6. The Automated Determination of Thiamine in Both Simple Solutions and Complex Preparations-A.J. Khoury and LJ. Cali 3:00 p.m.-7. Separation and Quantitative Determination of Adrenaline Using Thin Layer Chromatography-N.H. Choulis 3:15 p.m.-S. Molecular Interaction of Stereoisomers When in Solid State-N.H. Chou lis 3:30 p.m.-9. The Fluorometric Investigation of Certain Aralkylamines-W.E. Lange and J.M. Theodore, Jr. 3:45 p.m.-IO. A Study of Indicators and EDTA Solutions in the Assay of Calcium Salts-Albert C. Smith 4:00 p.m.-H. Quantitative Analysis of Some Pharmaceutical Powders by Water Absorption Technic-LR. Ciufo and R.M. Cox 4:15 p.m.-12. Determination of in Vitro Release Rates of Sustained Action Preparations by Paper Chromatography and Electrophoresis-H. Schriftman
third session Thursday, April 28, 9:00 a.m.-AdolphUS, Parlor A Presiding-Carl Rehm and John Wind heuser 9:00 a.m.-13. Chemi stry of the Lavine Method for Determining Methionine. Mechanism of Reversible Oxidation with lodineK.H. Gensch and T. Higuchi 9:15 a.m.-14. Ion Pair Extraction of Pharmaceutical Amines . Role of Dipolar Solvating Agents in Extraction of Dextromethorphan-T. Higuchi, A. Hurwitz, A. Michaelis and T. Tan
economics and administrative science Chairman-Joseph D. McEvilla Chairman -elect-Robert V. Evanson Vice Chairman-Richard L. Hull Secretary-Robert E. Abrams
fi rst session Tuesday, April 26, 2:00 p.m.-Baker, Terrace Room Academy section chairman-(Ieft to right, above) Leon Lachman, industrial pharmacy; Taito Soine, medicinal chemistry, and Joseph D. McEvilla, economics and administrative science .
Symposium-Drugs and Drug Products Moderator-George P. Hager 1. 2.
Academy section secretaries-(Ieft to right, below) Earl A. Kimes, industrial pharmacy; Eugene C. Jorgensen, medicinal chemistry , and Robert E. Abrams, economics and administrative science.
3.
A Drug Becomes a Drug Product-Jack Cooper, CIBA Pharmaceutical Company Generic Equivalence-A Second Look-Max S. Sadove, MD, University of Illinois, College of Med icine Drug Products for the Great Society-Martin Buchalter, Division of Public Welfare, New Jersey State Department of Insitutions and Agencies
second session-business Tuesday, April 26, 4:00 p.m.-Baker, Terrace Room
industrial pharmacy 9:30 a.m.-15. Ion Pair Extraction of Pharmaceutical Amines II. Extraction Profile of Chlorpheniramine-T. Higuchi, K. Kato, A. Michaelis and Diane Yamamoto 9:45 a.m.-16. Evaluation of a Spectropolarimetric-Penicillinase Method for Determining the Activity of Penicillin-T. Higuchi and C.E. Rasmussen 10:00 a.m.-17. Near-Infrared Spectroscopy of Amine SaltsJoseph E. Sinsheimer and Anne M. Keuhnelian 10:15 a.m.-18. Evaluation of Methods for Quenching Correction in Liquid Scintillation Counting of Carbon-14 in Tissue SamplesS. Riegelman and M.K. Asghar 10:30 a.m.-19. The Formation of Acetylcodeine Aspirin and Codeine-A.L. Jacobs, A.E. Dilatush, S. Weinstein and J.J. Windheuser 10:45 a.m.- -20. Nuclear Magnetic Resonance Spectra of AminesJ.E. Zarembo, W.E. Thompson, R.J. Warren and I.B. Eisdorfer 11:00 a.m.-21. Characterization of the Epoxidation Product of cis-4-(p-Chlorophenyl)-5-Cyanocyclohexene from NMR of Derivatives-David B. Roll and Alain C. Huitric 11:15 a.m.-22. The Detection of Some Form i minoesters and the Measurement of Their Rates of Formation Using NMR-Jay Nematollahi and L. Dallas Tuck 11:30 a.m.-23. A Quantum Chemical Study of Sydnones Using the w-Huckel Technic-L.B. Kier and E.B. Roche
Chairman-Leon Lachman Chairman -elect-Edward Hanus Vice Chairman-Herbert Lieberman Secretary-Earl A. Kimes
fi rst session Monday, April 25, 9:00 a.m.-DMA 300 Symposium-Plastic Containers for Pharmaceutical Products Presiding-John Autian
1.
Quality Manufacture of Plastic Pharmaceutical ContainersJules Pinsky 2. Toxicological Considerations in the Selection of Plastic Containers-Wallace L. Guess 3. A Study of Pharmaceuticals Stored i n Plastic Containers, U .S. Army Testing Program, Interim Report- H.M. Beal, P.J. Jannke and J. Pinsky 4. Discussion-speakers plus Richard W. Pecina
second session Monday, April 25, 1:30 p.m.-DMA 300
fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Cactus Room Symposium-The Application of Analytical Technics to the Stability of Drugs (Drug Standards, Analysis and Control and Scientific Sections Joint Symposium)
Symposium-New Pharmaceutical Packaging Equipment and Materials
and
Presiding-Roy Kuramoto Equipment 1. 2.
Chairman-Jonas Carol 1:30 p.m.-1. Application of Thin Layer Chromatography and Radioisotope Technics to Stability Studies-J.P. Comer, Eli Lilly and Company 2:00 p.m.-2. Applications of Gas-Liquid Chromatography to the Stability Testing of Drugs-C.R. Rhem , CI BA Pharmaceutical Company 2:30 p.m.-3. Functional Group Approach to Studies of Drug Stability-A.A. Forist, Upjohn Company 3:00 p.m.-4. Interrelation of Analytical Technic Applied to Stability Studies and Studies on Drug Homogeneity-D.H. Szulczeski, Parke, Davis & Co . 3:30 p.m.-Discussion of papers 4:00 p.m.-Panel discussion-E. Meyers, Food and Drug Ad ministration; T. Higuchi, University of Wisconsin School of Pharmacy; M. Auerbach, Sterling Winthrop Research Institute, and L. Chatten, University of Alberta (Canada) School of Pharmacy
Manufacturing
3. 4.
Production Experience with Glatt Fluid Bed Dryers-R.A. Hill and R. Cilento The Evaluation of the Deltapress, A Precompression Tablet Press-Daniel Pasquale Vial Sterilization and Filling on a Continuous Basis-Charles Riffkin Evaluation of the Zanasi Automatic Capsule Filler-L. Everett Stoyle, Jr.
Materials 1. 2.
Direct Compression Formulating-R. Cohn, R. Nessel and G. Reier The Formulation of Ion Exchange Resin Adsorbates in Topical Products-J.B. Ward and G.J. Sperandio
Packaging or Packaging Components 1. 2.
A Simple Data Retrieval System for Package ComponentsW.G. McDowell Recent Packaging Developments for Pharmaceutical AerosolsJohn J. Sciarra
Vol. NS6, No.3, March 1966
123
third session Tuesday, April 26, 9:00 a.m.-Baker, Crystal Ballroom Symposium-Present Concepts of the Biopharmaceutics of Oral Dosage Forms
4.
Th e Description and Evaluation of an In strumented Pilot Plant Lyophilizer and Its Versatility in Developing and Programming Production Cycles-Patrick P. DeLuca
eighth session
Presidin g-Martin Katz
Friday, April 29, 9:00 a.m.-Adolphus, Cactus Room
1.
Presiding-Arlyn Kinkel and Hyman Mitchner
2. 3.
4.
In Vitro Evalu ation of Dosage Form s-John H. Wood Design and Data Analy sis of Biopharmaceutical Studies in Man-John G. Wagner . Correlation of Gastrointestinal Ab so rptions and In Vitro DIssolution Kinetics of Drugs Contained in Oral Solid Dosa ge Forms-Gerhard Levy Discussion-speakers plus Ruth Levine and Anthony Glazko
fourth session-luncheon Tuesday, April 26, 12:00 noon-Baker, Lounge Address-Irving Marcus, superintendent of the chemical examining corps., U .S. Patent office
fifth session-business Tuesday, April26, 2:00 p.m.-Baker, Crystal Ballroom 1.
Call to order
2. Chairman ' s address-Leon Lachman 3. 4.
5. 6. 7. B. 9.
Secretary-treasurer's report-Earl A. Kimes Committee reports A. Program-Herbert Lieberman B . Membership-Edward Hanus C. National Committee on Regional Meetings-Roy Kuramoto D. Bylaws-Carl Lintner E. Acade m y-Jack Cooper F. Audio- vis ual-George Schneller G. Education-Stuart Eriksen H. Screening papers-Arnold Marcus I. Resolutions-Walter Charnicki Unfin i shed business New business Report of nominatin g committee-Jim McDavid Election and installation of officers Adjournment
sixth session Thursday, April 28, 9:00 a.m.-Adolphus, Roof Garden Presiding-Arnold Marcus and Harold Wolkoff 9:00 a.m.-I. Mechanism of Action of Starch as a Tablet Disinte· gra nt I. Preliminary Report. Factors that Affect Swelling of Starch Gra ins at 37°C-James T. Ingram and Werner Lowenthal 9:15 a.m.-2. Adhesion Tension Determinations for Evaluatin g Binders in Tabletting-J.K.J. Lim, H.O. Thompson and C. Pian· tadosi 9:30 a.m.-3. Exp erience in the Development of Directly Compressible Tablets Containing Potassium Chloride-Jack Lazarus and Leon Lachman 9:45 a.m.-4. Stability of Certified Dyes and Tablets III.-F.W. Goodhart, H.A. Lieberman, D.S. Mody and F.C. Ninger 10:00 a.m.-5. Further Studies on the Stability of FD&C Blue No.2 in Aqueous Solutions-C. Allen Brownley, Jr. and Leon Lachman 10:15 a.m.-6. A Controlled Release Dosage Form for Oral Administration-H.E. Huber, L.B. Dale and G.L. Christenson 10:30 a.m.-7. Sustained Release Plastic Matrix Dose Form I. Effect of External Factors on Drug Release-C.J. Endicott, J.D. Buddenhagen, P.W. Romig and R.H. Schleif 10:45 a.m.-B. Powder Flow Studies I. Instrumentation-Gerald Gold, Ronald N. Duvall and Blaze T. Palermo
seventh session Thursday, April 28, 1:00 p.m.-Adolphus, Roof Garden Presiding-Walter Charnicki
1. 2. 3.
124
Development and Technology of a Semi-Automated Continuous Extrusion Process for the Preparation of a Tablet GranulationH.T. Snyder, J.V. Battista and J. Michelson Rotary Tablet Machine Instrumentation-P.E. Wray, J.G. Vin· cent, F.W. Moller and G.J. Jackson The Formulation and Physical Properties of Aerosol Foams Intended for Top ica l Application of Medicinals-William A. Strickland, Jr.
Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION
9:00 a.m.-9. Powder Flow Studies II. Glidants-Gerald Gold, Ronald N. Duvall and Blaze T. Palermo 9:15 a.m.-10. Increased Hydrophilic Capacity of Polyethylene Glycol Ointment USP XVI-W. Chandranondnaiwinit a nd B. Sommers 9:30 a.m.-11. A Study of the Compressibility of Pharmaceutical Solids I. Instrumentation Employed and Preliminary Results Obtained-Jacob Varsano and Leon Lachman 9:45 a.m.-12. The Effects of Shear Processi ng and Thermal Exposure on the Viscosity-Stability of Polymer Solutions-D.R. Powell, J. Swarbrick and G.S. Banker .. 10:00 a.m.-B. Micromeritics of Granular Pharmaceutical Solids II. Factors Involved in the Sieving of Pharmaceutical GranulesDale E. Fonner, Gilbert S. Banker and James Swarbrick 10:15 a.m.-14 . Lined and Unlined Rubber Stoppers for Multiple Dose Vial Solutions II. Effect of Teflon Linin g on Preservati ve Sorption and Leaching of Extractives-Leon Lachman, Wayne A. Pauli Pravin B. Sheth and Miriam Pagliery 10:30 ~.m.-15. Stability Data Evaluation: Graphic Statistical Analysi s-L.L. Kaplan
medicinal chemistry Chairman-Taito O. Soine Chairman-elect-W. Lewis Nobles Vice Chairman-Irwin J. Pachter Secretary-Eugene C. Jorgensen
first session Monday, April 25, 9:00 a.m.-DMA 303 Pre siding-Lemont B. Kier and Ole Gisvold 9:00 a.m.-I. A Comparison of the Antimicrobial Prope rties of 5a· and 5/l-4-Azacholestanes-N.J. Doorenbos, K.R. Scott and L.M. Rice 9:15 a.m.-2. Hypoiodite Oxidation of 3a-Bromo and 3a-Chloro2/l-Hydroxy-5a-Androstan·17-0ne-G.W. Adelstein and R.E. Counsell 9:30 a.m.-3. A Novel Oxazole Synthesis-Roger Ketcham and Arnold Martin 9:45 a.m.-4. Basically Substituted Dioxolanes and Dioxane sH.V. Maulding, Jr. and Ole Gisvold 10:00 a.m.-5. The Preparation of Mixed Glycol Acetal Carbamates by Transacetalation of Certain Di- and Trihydric Alcohols-R.K. Rauch, Fred T. Semeniuk and Claude Piantadosi 10:15 a.m.-6. Amides, Esters of Heptamethylene and Octamethylene Moiety-Heino A. Luts and Jerome F. Grattan 10:30 a.m.-7. The Synthesis of Labeled Isomers of Dichlorodi· phenyldichloroethane (DDD)-R.E. Willette and R.E. Counsell .. 10:45 a.m.-B. Certain Esters of 1-, 2-, 3-Methyl-2-HydroxyqUinollzl' dines as Potential Local Anesthetic Agents-M.A. Zoglio, T .O. Soine and E.G. Rippie 11:00 a.m.-9. Anticonvulsants III. Alkyl Esters of 4-Bromo-2Sulfamoylbenzoic Acid and 4-Chloro·2-Sulfamoylbenzoic AcidGlenn H. Hamor and Bernard L. Reavlin 11:15 a.m.-10. The Synthesis of Some Disubstituted Cyanoacetamides as Potential Anticonvulsants-Herbert F. Schwartz II, Lee F. Worrell and Jaime N. Delgado 11:30 a.m.-11 . Structure·Activity Relationships among Some NAlkyl- and N-Dialkyl-2,2-Dialkylcyanoacetamides, Including 2Cyanoacyl-Piperidines, Pyrrolidines and Morpholines-Herbert F. Schwartz II, Robert G. Brown and Jaime N. Delgado 11:45 a.m.-12. Synthesis of Aldoxime Analogs of Arecholine as Cholinesterase Reactivators-J.N. Wells, J.N. Davisson and G.K.W. Vim
second session Monday, April 25, 1:30 p.m.-DMA 303 Presiding-Raymond E. Counsell and Eugene C. Jorgensen 1:30 p.m.-B: The Isopropylidene Derivatives of Digitoxin, Digoxin and Ouabain-O. Gisvold
pharmaceutical technology Chairman-Edward J. Rowe Chairman-elect-G.S. Banker Vice Chairman-F.P. Cosgrove Secretary-Ben F. Cooper
fi rst session Monday, April 25, 1:30 p.m.-DMA 301 Presiding-Edward J. Rowe Academy section chairman-(Ieft to right, above) Joseph P. Buckley, pharmacology and biochemistry; Arthur E. Schwarting, pharmacognosy and natural products, and Edward J. Rowe, pharmaceutical technology.
Academy section secretaries-(Ieft to right, below) Allan Conney, pharmacology and biochemistry; Jack L. Beal, pharmacognosy and natural products, and Ben F. Cooper, pharmaceutical technology.
1:30 p.m.-I. Mechanism of Action of Starch as a Disintegrating Agent in Aspirin Tablets-N.R. Patel and R.E. Hopponen 1:45 p.m.-2. Inositol as a New Base for Chewable Tablets-S.S. Nasir and LO. Wilken, Jr. 2:00 p.m.-3. Particle Size Distribution and Hopper Flow RatesE.D. Summer and H.O. Thompson 2:15 p.m.-4. Dye-Polyethylene Glycol 6000 Interactions in Film Coating Solutions and Their Effect on Color Uniformity-D.G. Bhatia, T.D. Sokoloski and V.N. Bhatia 2:30 p.m.-5. A Proposed Method of Testing Aerosol Preparations Using Chetomium Globosum as the Test Organism-J.W. Blasechi, Jr. and M. lannarone 2:45 p.m.-Business meeting A. Chairman's opening remarks-Edward J. Rowe B. Secretary-treasurer's report-Ben F. Cooper C. Appointment of committees D. Organizational structure of Academy of Pharma ceutical Sciences-discussion
second session Tuesday, April 26, 2:30 p.m.-Adolphus, French Roo m Presiding-Ben F. Cooper 1:45 p.m.-l4. Synthesis and Biological Evaluation of Analogs of Angiotensin II-E.C. Jorgensen and W. Patton 2:00 p.m.-l5. Thyroxine Analogs. 3,5-Thioalkyl and Thioaryl Thyronines-E.C. Jorgensen, R.O. Muhlhauser and R.A. Wiley 2:15 p.m.-l6. N-Ethyltryptamine Derivatives Related to Reserpine and Lysergic Acid-S. Sklar, K.A. Nieforth and M.H. Malone 2:30 p.m.-17. Spectrophotometric and Chemical Studies of 5Mercaptouracil , 5-Mercaptodeoxyuridine and Their S-Substituted Derivatives-T.J. Bardos and T.I. Kalman 2:45 p.m.-l8. Enzyme Inhibitors XIV. The Syntheses of Some 9-(m-Substituted Benzyl)-6-Substituted Purines as Inhibitors of Adenosine Deaminase-Howard J. Schaeffer and R.N. Johnson 3:00 p.m.-l9. Phosphorus-Nitrogen Compounds V. Some Gua nidine and 2-Aminopyrimidine Derivatives-L.A. Cates and N.M. Ferguson 3:15 p.m.-20. Phosphorus-Nitrogen Compounds VI. Some Phenethylamine Derivatives-LA. Cates, W.H. Lawrence and R.J. McClain 3:30 p.m.-21. Synthesis of N,N '-Haloacyl Analogs of p ,p ' -Oxydianiline as Potential Antineoplastic Agents-W.O. Roll 3:45 p.m.-22. Synthesis of 4-Substituted 7-Methylpyrrolo [2,3-d] Pyrimidines-Richard H. Hammer 4:00 p.m.-23. 5a-Aryl-6-Methylthymines as Potential Antimetabolites-J.H. Burckhalter and James L Brannon 4:15 p.m.-24. The Constituents of the Volatile Oil of Pycnanthemum Albescens-John T. Goorley
2:30 p.m.-6. Flavor Specialization-Fred Wesley 2:45 p.m.-7. A Rheological Evaluation of Lipophilic Suspending Agents. I. Dimethyl Dialkyl Ammonium Hectorite-C.T. Lesshafft, Jr. 3:00 p.m.-8. The Effect of Ultrasound on the Particle Size of Suspensions-M.A. Sheikh, J.C. Price and R.J. Gerraughty 3:15 p.m.-9. Drug Release Determination from Ointment Bases Using a Microbiological "Agar-Tube " Method-N.F. Billups 3:30 p.m.-lO. Dialysis Cell Method of Measuring Drug Release from Ointment Bases-J.M. Howze and N.F. Billups 3:45 p.m.-Business meeting continued A. Chairman'S remarks-Edward J. Rowe B. Committee reports C. Unfinished business D. Old business E. New business F. Report of nominating committee G. Adjournment
th i rd session Thursday, April 28, 1:30 p.m.-Adolphus, Grand Ballroom Pharmaceutical Technology and Pharmacology and Biochemistry Sections' Symposium-Psychopharmacology (see pharmacology and biochemistry for program)
third session-business Monday, April 25, 7:00 p.m.-Adolphus, Civic Room II
pharmacognosy and natural products
social Monday, April 25, 8:00 p.m.-Adolphus, Civic Room II
Chairman-Arthur E. Schwarting Chairman-elect-Varro E. Tyler, Jr. Vice Chairman-Gordon H. Svoboda Secretary-Jack L. Beal
fou rth session
fi rst session
Tuesday, April 26, 9:00 a.m.-Baker, Terrace Room
Monday, April 25, 9:00 a.m.-DMA 301
Symposium-Advances in Natural Product Chemistry
Presiding-Wilbert G. Walter and Ralph N. Blomster
(Medicinal Chemistry and Scientific Sections Joint Symposium)
Chairman-Howard J. Schaeffer 1.
Biosynthesis of Alkaloids-Edward Leete, University of Minnesota 2. RecentAdvances in the Chemistry of Naturally-Occurring Tumor Inhibitors-S. Morris Kupchan, University of Wisconsin 3. Solid-Phase Peptide Synthesis-Bruce Merrifield, Rockefeller Institute
9:00 a.m.-I. Alkaloids of the Rutaceae I.-Gordon H. Svoboda and Gerald A. Poore 9:15 a.m.-2. Cytotoxicity and Antitumor Activity of North Dakota Plants Part I. In Vitro Studies. I-A. Muni, W.H. Bhatti, LJ . Schermeister and M.C. Vincent 9:30 a.m.-3. Neriifolin: An Antitumor Agent from Thevefia Peruviana (Apocynaceae)-E. Bianchi, M.E. Caldwell and J.R. Cole 9:45 a.m.-4. Isolation of Antitumor Fractions of Abies Concolor (Pinaceae)-A. Ulubelen, M.E. Caldwell and J.R. Cole
Vol. NS6, No.3, March 1966
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Devoted to the fashion industry, the Apparel Mart is a center of attraction in Dallas. In this four-story structure housing 1,250 display rooms along four miles of corridors, the ladies will be entertained at their annual fashion show and luncheon. The Great Hall of the Apparel Mart will be used for the show. Special "pop" concerts also are given in the Hall by the Dallas Symphony Orchestra .
10:00 a.m.-5. Kilmer Prize paper 10:15 a.m.-6. Purification of Antibiotics-Michael Telepchak (APhA science fair winner) 10:30 a.m.-7. The Role of Ascorbic Acid Oxidase in the Hyoscyamine-Scopolamine Ratio in Datura Innoxia Miller-Helen Louise Rowland and Melvin R. Gibson 10:45 a.m.-8. Morning Glory Tissue Cultures: Growth and Examination for Indole Alkaloids-E.J. Staba and P. Laursen 11:00 a.m.-9. Isolation and Identification of Cantharidin in Epicauta Pestifera-W.G. Walter and J.F. Cole 11:15 a.m.-lO. Phytochemical I nvestigation I. Glycosides in Phytolacca Americana-W.G. Walter and H.M. Crosby 11:30 a.m.-ll. Studies on the Toxicity of Wisteria Seed-C. Dwayne Ogzewalla
second session Tuesday, April 26, 2:30 p.m.-Baker, Fiesta Room Presiding-Arthur E. Schwarting and Jack L. Beal 2:30 p.m.-12. Isolation of Two Bisbenzylisoquinoline Alkaloids from the Rhizomes and Roots of Xanthorhiza SimplicissimaJ.E. Knapp, F.T. Hussein, J.L. Beal, R.W. Doskotch and T. Tomimatsu 2:45 p.m.-l3. The Isolation and Identification of Three Alkaloids from the Bark of Xanthoxylum Elephantiasis Macf-A.T. Awad, J.L. Beal, S.K. Talapatra and M.P. Cava 3:00 p.m.-14. Occurrence of Amanita Toxins in American Collections of Deadly Amanitas-V.E. Tyler, Jr_, R.G. Benedict, L.R. Brady and J.E. Robbers 3:15 p.m.-15. Catharanthus Alkaloids X. Isolation of Lanceine, Ammocalline, Vinosidine and Catharine from C. Lanceus-R.N. Blomster, N.R. Farnsworth, D.J. Abraham, A.J. Sharkey, Jr. and H.H.S. Fong 3:30 p.m.-16. Catharanthus Alkaloids XI. Biological Effects of Fractions and Alkaloids Separated from C. Lanceus-N.R. Farnsworth, R.N. Blomster and J.P. Buckley 3:45 p.m.-Business meeting
pharmacology and biochemistry Chairman-Joseph P. Buckley Chairman-elect-J. William Keating Vice Chairman-Ewart A. Swinyard Secretary-Allan Conney
fi rst session Monday, April 25, 9:00 a.m.-DMA 302 Presiding-Ewart A. Swinyard and Vernon A. Green 9:00 a.m.-I. Attempts at Induced Agranulocytosis in Rats Using Dipyrone-N.M. Ferguson and Arthur F. Novak 9:15 a.m.-2. A New Treatment for Glutethimide IntoxicationGeorge G. Johnston, W.L. Guess and J. Autian
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Journal of the AMERICAN PHARMACEUTICAL ASSOCIATION
9:30 a.m.-3. Hepatic Toxicity of a Series of Organotin Compounds -David Calley, W.L. Guess and J. Autian 9:45 a.m.-4. Growth Inhibition of Mammalian Cell Cultures by Plastic Materials-S.A. Rosenbluth, W.L. Guess and J. Autian 10:00 a.m.-5. Antagonism of Convulsive and Lethal Effects Induced by Propoxyphene-R.E. Fiut, A.L. Picchioni, L. Chin 10:15 a.m.-6. Evaluation of Oral Dilution as a First Aid Measure in Poisoning-M.L. Henderson, L. Chin and A.L. Picchioni 10:30 a.m.-7. The Effect of Chronic Nortriptyline Pretreatment on the Acute Toxicity of Various Medicinal Agents in Rats-D.B. Meyers, D.O. Kanyuck and R.C. Anderson 10:45 a.m.-8. Chronic Effects of Thyroxine and Pargyline in RatsA.B. Mendillo, A.M. Guarino and J.J. DeFeo 11:00 a.m.-9. Automated Nephelometric Determination of Rat Liver Glycogen in Adrenal Steroid Bioassays-W.F. Beyer 11:15 a.m.-lO. Alterations in Hyaluronidase Activity and Other Effects of Prolonged Heat Exposure in the Rat-M.M. Clay and M.W. Adler 11:30 a.m.-ll. A Survey of Tetracycline Deposition in the Artery of the Newborn-D.M. Stuart and M.M. Mallin 11:45 a.m.-lla . A Preliminary Report on the in Vitro Antimicrobial Activity of Neomycin Undecylenate Cream on Common Skin Pathogens-Chester F. Koda and Joseph P. Miale
second session Monday, April 25, 1:30 p.m.-DMA 302 Presiding-Nathan Watzman and Harold H. Wolf 1:30 p.m.-12. Antagonism of Free Fatty Acid Release from Rat Epididymal Fat Tissue by Desmethylimipramine-K.L. Finger and J.G. Page 1:45 p.m.-l3. Interaction of Various Phenylethylamines with the Adrenergic-Adipose Tissue, Receptor System, in Vitro-K.F. Finger and D.R. Feller 2:00 p.m.-14. The Effect of Hypothermia on Chlorpromazine Induced Bradycardia and Hypotension in the Rat-K.F. Finger, R.L. Cavanagh and E.E. Moog 2:15 p.m.-15. The Utility of Two Convulsant Technics as Indicators ofCNS Excitability-H.H. Wolf and G.A. Stock, Jr. 2:30 p.m.-16. The Effects of Environmental Temperature on the LD50 of Some CNS Stimulants-J.A. Hall, R.B. Nelson and A.I. Edlin 2:45 p.m.-17. Comparison of Different Photobeam Arrangements for Measuring Spontaneous Activity of Mice-N. Watzman, H. Barry, III, W.J. Kinnard, Jr. and J.P. Buckley 3:00 p.m.-18. Behavioral Effects of Oral Compared with Intraperitoneal Doses of Chlorpromazine-H. Barry, III, N. Watzman, J.P. Buckley and W.J. Kinnard, Jr. 3:15 p.m.-19. The Effect of Some Psychotropic Agents on Peripheral Nerve Conduction Rate-Jack K. Pruett and Byron B. Williams 3:30 p.m.-20.' The Effects of Steroids and LSD on the Oxygen Consumption of Rat Brain Homogenates-V.A. Green and T.M. Glenn
3:45 p.m.-21. A Study of the I nteractions of Steroids, Lysergic Acid Diethylamide (LSD), Serotonin (5-HT) and I proniazid on Hexobarbital-Induced Narcosis-T.M. Glenn and V.A. Green 4:00 p.m.-22. Effect of Diphenylhydantoin on Hexobarbital Sleep Time in Mice and Rats-M. Tannhauser, J.W. Kemp, E.A. Swinyard and Louis S. Goodman 4:15 p.m.-23. Actions of Sydnones on Gamma-Aminobutyric Acid Levels in Mouse Brain-L.E. Fox
11:00 a.m.-32. Synthesis of N-Methyl C14 Atropine-T.E. Eling, G.C. Schmidt, J.C. Drach and H.C. Shirkey 11:15 a.m.-33. Preliminary Evidence for the Existence of an Atropine-Degrading Enzyme in Goat Serum-R.G. Miller, G.C. Schmidt and H.C. Shirkey 11:30 a.m.-34. Effects of D-Panthenol Enrichment on Subsequent Drug Action in Smooth Muscle and Skeletal Muscle of RodentsJ.W. Kosh and R.G. Brown 11:45 a.m.-35. Characterizations of the Action of ImipramineC.D. Ross and R.G. Brown
third session Thursday, April 28, 9:00 a.m.-Adolphus, Danish Room Presiding-William J. Kinnard and Marvin H. Malone
9:00 a.m.-24. Desoxycholic Acid Enhancement of Reserpine's Blepharoptotic Activity-M.H. Malone, H.I. Hochman and K.A. Nieforth 9:15 a.m.-25. The Radioautographic Measurement of Tritiated Thymidine Uptake by a Malignant Cell Line on Exposure to Certain Glucocorticoids I. Adaptation of Radioautographic TechnicSr. M. Consolatrix Jakschik, SAC, Denise M. Eno and C. Kaplan 9:30 a.m.-26. The Radioautographic Measurement of Tritiated Thymidine Uptake by a Malignant Cell Line on Exposure to Certain Glucocorticoids II. Effect on Cell Proliferation-Sr. M. Consolatrix Jakschik, SAC, Denise M. Eno and C. Kaplan 9:45 a.m.-27. A New Technic for Evaluating Anti-Ulcer Drugs; Gastric Erosions Produced by Insulin Hypoglycemia-W.G. Groves, P. Setler and D. Arbakov 10:00 a.m.-28. The Evaluation of Antispasmodic and Related Activity in the Intact Dog II.- N. Katz and H.J. Jenkins 10:15 a.m.-29. Metabolism of dl-Amphetamine Sulfate in the Rat-A.A. Noujaim, P.L. Ziemer and J.E. Christian 10:30 a.m.-3D. Effects of Estradiol and Progesterone on the Metabolism of Chlorpromazine-T.S. Miya, E.H. Adams and R. Saunders 10:45 a.m.-31. Accelerated Metabolism of Ethanol in the RatElliot Spector and John F. Reinhard
fou rth session Thursday, April 28, 1:30 p.m.-Adolphus, Grand Ballroom Symposium-Psychopharmacology (Pharmacology and Biochemistry and Pharmaceutical Technology Sections Joint Symposium)
Chairman-Joseph P. Buckley 1. 2. 3. 4. 5. 6.
Introductory Remarks-Joseph P. Buckley, University of Pittsburgh school of pharmacy Biochemical and Physiological Basis of Mental DiseaseBernard B. Brodie, National Heart Institute Chemo-Pharmacologic Approaches to the Development of Psychotropic Drugs-John H. Biel, Aldrich Chemical Company Neuropharmacologic Evaluation of Drugs Used in PsychiatryDavid H. Tedeschi, Smith Kline & French Laboratories Initial Preclinical Screening in Psychopharmacology-William J. Kinnard, Jr., University of Pittsburgh school of pharmacy Clinical Efficacy of Psychopharmacological Agents-Leo E. Hollister, MD, Veterans Administration Hospital
fifth session-business Friday, April 29, 10:00 a.m.-Adolphus, Parlor A
section on historical pharmacy
12:00 noon-B. Historical Sketch of the Pharmaceutical Industry in Puerto Rico-Luis Torres Diaz
Chairman-Norman H. Franke Vice Chairman-Herbert C. Raubenheimer Secretary-Esther Jane Wood Hall Delegates to the House of Delegates-George W. Grider and George Osborne
second session
fi rst session
Presiding-Norman H. Franke, chairman
Monday, April 25, 9:00 a.m.-DMA 200 Presiding-Norman H. Franke, chairman
9:00 a.m.-I.
Business session A. B. C. D.
E.
Tuesday, April 26, 2:00 p.m.-DMA 200
Call to order Chairman's address-Norman H. Franke Secretary's report-Esther Jane Wood Hall Appointment of committees Presentation of papers
9:15 a.m.-2. Pharmacy One Hundred Years Ago-O.L. Campbell and C.L. Huyck 9:30 a.m.-3. A Pioneer Drug Store in Vernon, Texas-Edwin S. Malone, III 9:45 a.m.-4. Pharmacy and Pharmacists in Colonial Boston, Massachusetts, Part One- H.C. Raubenheimer 10:00 a.m.-5. John Bull's Medicine-William H. Helfand 10:15 a.m.-6. The New York Branch of the American Pharmaceutical Association-Frank J. Pokorny 10:30 a.m.-7. Philip Charles Candidus: Pioneer Alabama Pharmacist-Lela Irwin Legare 10:45 a.m.-8. Rough and Ready Research-1887 Style-George A. Bender 11:00 a.m.-9. History of the Development of Fair Trade-Norman A. Campbell 11:15 a.m.-lO. The Doll Nina-M.L. Neuroth 11:30 a.m.-ll. Interesting Facets of Medico-pharmaceutical Conditions in the Confederacy-Norman H. Franke 11:45 a.m.-12. Pharmacy-A Stable Profession-Laurence D. Lockie
2:00 p.m.-14. The Early Years of Ohio Northern University College of Pharmacy, V-C.O. Lee 2:15 p.m.-15. History of Xavier University's College of Pharmacy-Y.A. Soucy and C.L. Huyck 2:30 p.m.-16. Pharmacy and Pharmacists in Colonial Boston, Massachusetts, Part Two-H.C. Raubenheimer 2:45 p.m.-17. The Texas State Historical Survey Committee Medallion Pharmacy in Jefferson, Texas and SurroundingsMrs. Dan Lester 3:00 p.m.-18. The Founding of the American College of Apothecaries-E.W. Stieb 3:15 p.m.-19. Rise and Demise of the Spanish Edition of the U.S. Pharmacopeia-Nydia M. King 3:30 p.m.-20. Medicine and Pharmacy in the Torah and Talmud: I. Birth Control and Contraception-Mark M. Lukens 3:40 p.m.-21. The Pharmaceutical Exhibition at the SmithsonianSami K. Hamarneh 3:50 p.m.-22. The Restoration of a New Jersey Pharmacy-1890John L. Voigt 4:00 p.m.-23. Pharmacy and Medicine Aboard the New England Whaleships-George E. Osborne and Arthur G. Lipman 4:10 p.m.-24. The First Day-October 26, l886-George A. Bender 4:20 p.m.-25. Early Years of Pharmacy Organization in Dallas, Texas-Esther Jane Wood Hall 4:30 p.m.-26. Business session A. Unfinished business B. Report of committees C. Election and installation of officers D. Adjournment Vol. NS6, No.3, March 1966
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