Abstracts of Papers
259
g a m m a emitter tracers provides the pure left heart curve, and a precise too./ ior calculation of both atrial and ventricular rates of emptying, and ventrieular volumes. Large experimental evidence is presented and the importance of the new technique is emphasized.
traduit l'dtat fonctionnel de l'organe. L'injection d'une quantitd de rose bengale marqud n'entralnant qu'une irradiation minime permet d'obtenir un h6patogramme qui renseigne sur la situation, les dimensions, les contours et l'homogdnditd du lois.
2O8
Ilal-labelled D i o d r a s t a n d R o s e B e n g a l T r a c e r s : T h e i r V a l u e in I n v e s t i g a t i n g Kidney and Liver Functions. G. V.
M e s u r e c o n t i n u e , in vivo, s u r la s o u r i e s de la c o n c e n t r a t i o n s a n g u i n e d e s i s o t o p e s a r a y o n n e m e n t [ 3 - m o u et n o t a m m e n t du c a r b o n e - 1 4 . P. BONET-MAURY, A. DEYSINE, et F. PATTI, I n s t i t u t d u R a d i u m , Paris, France. L'oreille d'une souris injectde avec du carbone14 prdsente une activitd externe facilement mesurable avec un compteur cloche ordinaire /i fen~tre mince (2 mg/cm')). La souris est immobilisde sur une planchette en plexiglass; sa t6te est masqude par un dcran de plomb, percd d ' u n trou laissant passer l'oreille. Le rayonnement j3 6mis est recueilli par un compteur cloche, plac6 audessus de l'oreille et enresgistrd, apr~.s amplification convenable. L' enregistrement continu de l'activitd de l'oreille permet de ddterminer sur une m~me souris vivante, placde dans des conditions physiologiques acceptables, route ]a courbe de concentration sanguine en C 1~, depuis le ddbut de /'injection. 209
l~tude f o n c t i o n n e l l e a n d m o r p h o l o g i q u e du l o i n p a r le r o s e b e n g a l e m a r q u e a l'iode-131. H . RENAULT et C. JACRUIER, H d p i t a l S t - A n t o i n e , et H . et J . JAMMET, F o n d a t i o n C u r i e , Paris, F r a n c e . U n e pnssibilitd nouvelle d'utilisation du rose bengale comme dpreuve fonctionnelle hdpatique a dt6 envisagde en m a r q u a n t ce colorant par le radiolode-131. La ddtection hors de l'organisme du rayonnement / d m i s pcrmet, en outre, d'obtenir une image scintillographique du fois. Des dtudes effectudes sur le rat et le chien ent prdcisd: la courbe d'dpuration sanguine, la courbe de fixation et d'dlimination hdpatique; l'dlimination fdcMe et urinaires la tr6s faible fixation thyroidienne et musculaire. Les calculs effectuds h partir de ces rdsultats ont dtabli d'une part la possibilitd d'obtention d ' u n scintillogramme lors de la fixation hdpatique maximum, d'autre part l'inocuitd de la mdthode compte-tenu de l'irradiation totale de l'organisme et partielle du foie et de l'intestin. La mdthode appliqude chez l ' h o m m e a confirmd les espoirs suseitds par l'expdrimentation animals. La reprdsentation graphique en coordonndes logarithmiques de la mesure indirecte de la fixation hdpatique condiut fi des droites dont la pente
210
TAPLIN, O . M . MEREDITH, JR., H . KADE, a n d C. C. WINTER, U n i v e r s i t y of C a l i f o r n i a , Los A n g e l e s , U . S . A . Recent progress in the development of external tracer techniques for measuring liver and kidney functions with II~Mabelled Rose Bengal and Diodrast are described. Results of laboratory and clinical investigations are presented and interpreted. The present status of each test is summarized. The Diodrast-I TM renogram is not only a useful tool ['or further investigation in renal physiology but also has distinct usefulness in clinical urology, especially as a rapid screening procedure to detect unilateral renal disorders in children and young adults with hypertension. T h e Rose Bengal-I TM hepatogram is presently the most sensitive specific test for polygonal cell function of the liver. When the test is used repeatedly in jaundiced patients, results correlate well with the clinical findings and indicate the underlying pathophysiological disturbances more quickly than do indirect biochemical liver tests. "FILe hepatogram provides data on biliary tract patency and/or bile flow interference, and therefore has distinct value in the differential diagnosis of medical versus surgical jaundice. The use of a mixture of BSP and Rose Bengal-I TM as a liver stress test promises to be a means for increasing the sensitivity of the procedure to tile point where a negative stress test is indicative of the absence of significant hepatic pathology. These investigations demonstrate the fundamental usefulness in research and the clinical applicability of dynamic external tracer techniques which permit the simultaneous measurement of multiple physiological events and evaluation of specific renal and hepatic function as well as patency of the upper urinary passages and biliary tract. 211
Electron-exchange R e a c t i o n s of Fe(II)Fe(III) and C o ( I I ) - C o ( I I I ) C o m p l e x e s . F. S. DAINTON, G. S. LAURENCE, W . SCHNEIDER, D. R . STRANKS, a n d M . S. VAIDYA. The influence of various ligands on the rates of electron exchange between complexes of Fe(II) F e ( l I I ) and of C o ( I I ) - C o ( I I I ) has been investigated.