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Etude evolutive electro-clinique de la maladie de Creutzfeldt-Jakob: A propos de six cas
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C-12.03 COMPRESSED POLYGRAPHIC RECORDS OF PERIODIC PHENOMENA IN CASES WITH SEVERE VASCULAR Y. Tsunashima, S. KataLESIONS OF BRAIN-STEM. yama, S. Yokoyama, T. Kimura and M. Araki (Mibu, Japan)
ric and EEG results as an expression of a pharmace-dynamic Buflomedil effect which leads to acceleration and an increase in rapid EEG activity (Desynchronization) and a psychometric performance increase.
Cyclic changes of the electrophysiological and autonomic functions were often manifested with development of cerebral damage in cerebrovasBut it is usuallv difficult cular accidents. to correlate variations in EEG, eye movements, respiration, etc. with sites of vascular lesions, efficacy of drug therapy and prognosis of the patients. In this study, compressed recordings were performed to analyse periodicity of these variables, including power spectral array of EEG, integrated respiration curves and cardiotachogram as well as EOG, EMG This monitorand plethysmogram of the finger. ing system permits macroscopic observation of periodic phenomena. Periodic phenomena with periods of 60 to 100 set were observed in relatively mild cases of intracranial hypertension with preserved consciousness, while those of variable and longer periods, more than 6 min, that is, plateau waves of Lundberg, were recorded during the decorticate stage, which suggested both release from the forebrain inhibitory system and disturbed mechanism of the brain-stem This periodicity was temoscillation center. porarily interrupted by injection of chlorpromazine or ventricular drainage of CSF, and finally abolished in the decerebrate stage.
C-14.04 EEG STUDY DURING WAKING AND SPONTANEOUS SLEEP STATES OF CERTAIN "RHYTHMIC TEMPORAL OISCHARGES" WITHOUT CLINICAL SIGNIFICANCE. I. Picornell Darder, G. de Blas, M.J. Picornell, A.P. Lozano and M. Conde Lopez (Madrid, Spain) (Madrid, Spain)
D-17.01 EEG AND PSYCHOMETRIC EVALUATION IN LONG-TERM STUDIES WITH AN ANTIHYPOXIC DRUG. R. Krauskopf (Munich, W. Germany) 53 test persons were used to compare the effect of Buflomedil with that of placebo after an observation oeriod of 180 davs (26 men. 32 women, average age 66.3 and 65.5, respectively). They underwent outpatient treatment for in32 test percreasing insufficiency symptoms. sons were oiven 200 ma Buflomedil 3 times a 'day for 180 days and 26 test persons were given placebo 3 times a day for 180 days. Prior to and after the beginning of medication psychometric and EEG examinations were carried out.The derivations of the riqht Parieto-occipital region were automatically analysed (interval analysis). The psychometric tests revealed better results after the termination of treatment than at the first examination. Part of this increase in performance must be regarded as a simple training gain. However, in conjunction with the EEG examination, part of this increase in performance can be regarded as an effect of Buflomedil. The EEG examination after Buflomedil.showed a shifting of the dominant frequency from the lower to the upper wave bands and an increase in performance in the alpha band and the adjacent upper theta bands, as well as in the lower beta bands. We regard the psychomet-
The existence of subclinical rhythmic theta discharges in the temporal regions in non-epileptic patients was described by Gibbs and Gibbs under the name of "Psychomotor variant type of discharge" and later by Arfel et al. (1978) who proposed the term of "rhythmic temporal discharges". We have performed an EEG and polygraphic waking and spontaneous sleep evolutive study of 5 patients (3 males and 2 females) whose ages were in the range of 10 and 53 years and who presented rhythmic temporal discharges apparently without pathological significance. All the cases showed sporadic discharges during the waking state, both bilateral and unilateral, and increased by hyperventilation (5 out of 6); they reappeared during the REM sleep phase with the same morphological characteristics. During slow sleep we registered no discharges. The literatureis reviewed and some consideretions are made with respect to their significance. A-15.10 ETUDE EVOLUTIVE ELECTRO-CLINIQUE DE LA MALADIE DE CREUTZFELDT-JAKOB: A PROPOS DE SIX CAS. M.CondeLopez, I. Picornell Darder, A.P. Lozano, A. Caro-Paton, G. Blas, M.J. Picornell et V. Conde Lopez. (Madrid, Spain) Etude evolutive electro-clinique (phase initiale, developpement et phase terminale) de 6 patients avec le diagnostic de maladie de Creutzfeldt-Jakob: dans 4 cas avec verification anatomopathologique et dans 2 cas avec des 11 s'acriteres electro-cliniques uniquement. git de 5 femmes et d'un homme entre 45 et 73 ans avec une periode d'evolution moyenne de la maladie de 4 mois. Nous avons realise en moyenne, 7 etudes par patient, parmi lesquelles 3 sont des etudes polygraphiques de longue durec. Dans 4 cas nous avons fait des etudes EEG des les phases les plus precoces de la maladie, et chez 2 patients nous avons constate la mort. Nous etudions les modifications cycliques spontanees des activites periodiques et les correlations cortico-vegetatives qui constituent une partie integrante de l'alternance cyclique et son evolution au long de la maladie. Nous avons etudie egalement l'effet du diazepam intraveineux chez 2 de ces patients.
C-12.03 COMPRESSED POLYGRAPHIC RECORDS OF PERIODIC PHENOMENA IN CASES WITH SEVERE VASCULAR Y. Tsunashima, S. KataLESIONS OF BRAIN-STEM. yama, S. Yokoyama, T. Kimura and M. Araki (Mibu, Japan)
ric and EEG results as an expression of a pharmace-dynamic Buflomedil effect which leads to acceleration and an increase in rapid EEG activity (Desynchronization) and a psychometric performance increase.
Cyclic changes of the electrophysiological and autonomic functions were often manifested with development of cerebral damage in cerebrovasBut it is usuallv difficult cular accidents. to correlate variations in EEG, eye movements, respiration, etc. with sites of vascular lesions, efficacy of drug therapy and prognosis of the patients. In this study, compressed recordings were performed to analyse periodicity of these variables, including power spectral array of EEG, integrated respiration curves and cardiotachogram as well as EOG, EMG This monitorand plethysmogram of the finger. ing system permits macroscopic observation of periodic phenomena. Periodic phenomena with periods of 60 to 100 set were observed in relatively mild cases of intracranial hypertension with preserved consciousness, while those of variable and longer periods, more than 6 min, that is, plateau waves of Lundberg, were recorded during the decorticate stage, which suggested both release from the forebrain inhibitory system and disturbed mechanism of the brain-stem This periodicity was temoscillation center. porarily interrupted by injection of chlorpromazine or ventricular drainage of CSF, and finally abolished in the decerebrate stage.
C-14.04 EEG STUDY DURING WAKING AND SPONTANEOUS SLEEP STATES OF CERTAIN "RHYTHMIC TEMPORAL OISCHARGES" WITHOUT CLINICAL SIGNIFICANCE. I. Picornell Darder, G. de Blas, M.J. Picornell, A.P. Lozano and M. Conde Lopez (Madrid, Spain) (Madrid, Spain)
D-17.01 EEG AND PSYCHOMETRIC EVALUATION IN LONG-TERM STUDIES WITH AN ANTIHYPOXIC DRUG. R. Krauskopf (Munich, W. Germany) 53 test persons were used to compare the effect of Buflomedil with that of placebo after an observation oeriod of 180 davs (26 men. 32 women, average age 66.3 and 65.5, respectively). They underwent outpatient treatment for in32 test percreasing insufficiency symptoms. sons were oiven 200 ma Buflomedil 3 times a 'day for 180 days and 26 test persons were given placebo 3 times a day for 180 days. Prior to and after the beginning of medication psychometric and EEG examinations were carried out.The derivations of the riqht Parieto-occipital region were automatically analysed (interval analysis). The psychometric tests revealed better results after the termination of treatment than at the first examination. Part of this increase in performance must be regarded as a simple training gain. However, in conjunction with the EEG examination, part of this increase in performance can be regarded as an effect of Buflomedil. The EEG examination after Buflomedil.showed a shifting of the dominant frequency from the lower to the upper wave bands and an increase in performance in the alpha band and the adjacent upper theta bands, as well as in the lower beta bands. We regard the psychomet-
The existence of subclinical rhythmic theta discharges in the temporal regions in non-epileptic patients was described by Gibbs and Gibbs under the name of "Psychomotor variant type of discharge" and later by Arfel et al. (1978) who proposed the term of "rhythmic temporal discharges". We have performed an EEG and polygraphic waking and spontaneous sleep evolutive study of 5 patients (3 males and 2 females) whose ages were in the range of 10 and 53 years and who presented rhythmic temporal discharges apparently without pathological significance. All the cases showed sporadic discharges during the waking state, both bilateral and unilateral, and increased by hyperventilation (5 out of 6); they reappeared during the REM sleep phase with the same morphological characteristics. During slow sleep we registered no discharges. The literatureis reviewed and some consideretions are made with respect to their significance. A-15.10 ETUDE EVOLUTIVE ELECTRO-CLINIQUE DE LA MALADIE DE CREUTZFELDT-JAKOB: A PROPOS DE SIX CAS. M.CondeLopez, I. Picornell Darder, A.P. Lozano, A. Caro-Paton, G. Blas, M.J. Picornell et V. Conde Lopez. (Madrid, Spain) Etude evolutive electro-clinique (phase initiale, developpement et phase terminale) de 6 patients avec le diagnostic de maladie de Creutzfeldt-Jakob: dans 4 cas avec verification anatomopathologique et dans 2 cas avec des 11 s'acriteres electro-cliniques uniquement. git de 5 femmes et d'un homme entre 45 et 73 ans avec une periode d'evolution moyenne de la maladie de 4 mois. Nous avons realise en moyenne, 7 etudes par patient, parmi lesquelles 3 sont des etudes polygraphiques de longue durec. Dans 4 cas nous avons fait des etudes EEG des les phases les plus precoces de la maladie, et chez 2 patients nous avons constate la mort. Nous etudions les modifications cycliques spontanees des activites periodiques et les correlations cortico-vegetatives qui constituent une partie integrante de l'alternance cyclique et son evolution au long de la maladie. Nous avons etudie egalement l'effet du diazepam intraveineux chez 2 de ces patients.